Passing the vascular barrier: endothelial signaling processes controlling extravasation
N Wettschureck, B Strilic… - Physiological …, 2019 - journals.physiology.org
A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …
An update on the biology of sphingosine 1-phosphate receptors
Sphingosine 1-phosphate (S1P) is a membrane-derived lysophospholipid that acts primarily
as an extracellular signaling molecule. Signals initiated by S1P are transduced by five G …
as an extracellular signaling molecule. Signals initiated by S1P are transduced by five G …
Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
V Brinkmann, A Billich, T Baumruker… - Nature reviews Drug …, 2010 - nature.com
The discovery of fingolimod (FTY720/Gilenya; Novartis), an orally active immunomodulatory
drug, has opened up new approaches to the treatment of multiple sclerosis, the most …
drug, has opened up new approaches to the treatment of multiple sclerosis, the most …
Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs
JG Cyster, SR Schwab - Annual review of immunology, 2012 - annualreviews.org
Much has been learned about how cells enter lymphoid tissues. But how do they leave?
Sphingosine-1-phosphate (S1P) has emerged over the past decade as a central mediator of …
Sphingosine-1-phosphate (S1P) has emerged over the past decade as a central mediator of …
[HTML][HTML] Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer
Inflammatory bowel disease is an important risk factor for colorectal cancer. We show that
sphingosine-1-phosphate (S1P) produced by upregulation of sphingosine kinase 1 (SphK1) …
sphingosine-1-phosphate (S1P) produced by upregulation of sphingosine kinase 1 (SphK1) …
Crystal structure of a lipid G protein–coupled receptor
The lyso-phospholipid sphingosine 1-phosphate modulates lymphocyte trafficking,
endothelial development and integrity, heart rate, and vascular tone and maturation by …
endothelial development and integrity, heart rate, and vascular tone and maturation by …
Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond
GT Kunkel, M Maceyka, S Milstien… - Nature reviews Drug …, 2013 - nature.com
The bioactive lipid sphingosine-1-phosphate (S1P) is involved in multiple cellular signalling
systems and has a pivotal role in the control of immune cell trafficking. As such, S1P has …
systems and has a pivotal role in the control of immune cell trafficking. As such, S1P has …
The Concise Guide to PHARMACOLOGY 2013/14: G protein‐coupled receptors
SPH Alexander, HE Benson… - British journal of …, 2013 - Wiley Online Library
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
[HTML][HTML] Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection
JR Teijaro, KB Walsh, S Cahalan, DM Fremgen… - Cell, 2011 - cell.com
Cytokine storm during viral infection is a prospective predictor of morbidity and mortality, yet
the cellular sources remain undefined. Here, using genetic and chemical tools to probe …
the cellular sources remain undefined. Here, using genetic and chemical tools to probe …