Advances in machining of hard tissues–From material removal mechanisms to tooling solutions

Y Zhang, JA Robles-Linares, L Chen, Z Liao… - International Journal of …, 2022 - Elsevier
The machining of hard tissues, such as cortical bone and cancellous bone in human bodies
and enamel and dentin in teeth, is an essential process in orthopaedics, neurosurgery and …

Craniobot: A computer numerical controlled robot for cranial microsurgeries

L Ghanbari, ML Rynes, J Hu, DS Schulman… - Scientific reports, 2019 - nature.com
Over the last few decades, a plethora of tools has been developed for neuroscientists to
interface with the brain. Implementing these tools requires precisely removing sections of the …

Assembly and operation of an open-source, computer numerical controlled (CNC) robot for performing cranial microsurgical procedures

ML Rynes, L Ghanbari, DS Schulman, S Linn… - Nature protocols, 2020 - nature.com
Cranial microsurgery is an essential procedure for accessing the brain through the skull that
can be used to introduce neural probes that measure and manipulate neural activity …

Closed-loop, ultraprecise, automated craniotomies

N Pak, JH Siegle, JP Kinney… - Journal of …, 2015 - journals.physiology.org
A large array of neuroscientific techniques, including in vivo electrophysiology, two-photon
imaging, optogenetics, lesions, and microdialysis, require access to the brain through the …

Surgical puncture access

NDM Begg - US Patent 8,419,764, 2013 - Google Patents
BACKGROUND In minimally invasive Surgical procedures, one or more tissue layers must
sometimes be punctured without direct visualization of an instrument tip in order to gain …

Autonomous Robotic Drilling System for Mice Cranial Window Creation

E Zhao, MM Marinho, K Harada - arXiv preprint arXiv:2406.14135, 2024 - arxiv.org
Robotic assistance for experimental manipulation in the life sciences is expected to enable
favorable outcomes, regardless of the skill of the scientist. Experimental specimens in the life …

Surgical puncture access with preload lock

NDM Begg - US Patent 8,894,679, 2014 - Google Patents
BACKGROUND In minimally invasive Surgical procedures, one or more tissue layers must
sometimes be punctured without direct visualization of an instrument tip in order to gain …

Principles of computer numerical controlled machining applied to cranial microsurgery

L Ghanbari, M Rynes, JJ Hu, DS Shulman, G Johnson… - bioRxiv, 2018 - biorxiv.org
Over the last decade, a plethora of tools have been developed for neuroscientists to
interface with the brain. Implementing these tools requires precise removal of sections of the …

Method for automated opening of craniotomies for mammalian brain access

N Pak, JP Kinney, ES Boyden - US Patent 10,820,914, 2020 - Google Patents
A method for automated opening of craniotomies includes, under the control of a computer
processor, drilling into a skull for a predetermined distance and determining when there is a …

Surgical puncture access

NDM Begg - US Patent 9,039,723, 2015 - Google Patents
BACKGROUND In minimally invasive Surgical procedures, one or more tissue layers must
sometimes be punctured without direct visualization of an instrument tip in order to gain …