Transposable elements and retroviruses are found in most genomes, can be pathogenic
and are widely used as gene-delivery and functional genomics tools. Exploring whether …

Current approaches for inserting autonomous transgenes into the genome, such as CRISPR–
Cas9 or virus-based strategies, have limitations including low efficiency and high risk of …

R2 elements exclusively insert into 28S rRNA genes (Figure 1). As a result of this specificity,
R2 is one of the more tractable mobile elements to study and, thus, is now among the best …

DNA transposons are the mobile elements that move by a “cut and paste” mechanism (1, 2).
In contrast, retrotransposons encode reverse transcriptase, and move by a “copy and paste” …

The shell color of the Mollusca has attracted naturalists and collectors for hundreds of years,
while the molecular pathways regulating pigment production and the pigments themselves …

R2 non-long terminal repeat (non-LTR) retrotransposons are among the most extensively
distributed mobile genetic elements in multicellular eukaryotes and show promise for …

Non-LTR retrotransposons are an important class of mobile elements that insert into host
DNA by target-primed reverse transcription (TPRT). Non-LTR retrotransposons must bind to …

Background R2 elements are a clade of early branching Long Interspersed Elements
(LINEs). LINEs are retrotransposable elements whose replication can have profound effects …

How asexual reproduction shapes transposable element (TE) content and diversity in
eukaryotic genomes remains debated. We performed an initial survey of TE load and …

Long interspersed elements (LINEs) replicate by target primed reverse transcription (TPRT).
Insertion involves two half reactions. Each half reaction involves DNA cleavage followed by …