Integration site selection by retroviruses and transposable elements in eukaryotes
Transposable elements and retroviruses are found in most genomes, can be pathogenic
and are widely used as gene-delivery and functional genomics tools. Exploring whether …
and are widely used as gene-delivery and functional genomics tools. Exploring whether …
Harnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor loci
X Zhang, B Van Treeck, CA Horton, JJR McIntyre… - Nature …, 2024 - nature.com
Current approaches for inserting autonomous transgenes into the genome, such as CRISPR–
Cas9 or virus-based strategies, have limitations including low efficiency and high risk of …
Cas9 or virus-based strategies, have limitations including low efficiency and high risk of …
Integration, regulation, and long‐term stability of R2 retrotransposons
TH Eickbush, DG Eickbush - Mobile DNA III, 2015 - Wiley Online Library
R2 elements exclusively insert into 28S rRNA genes (Figure 1). As a result of this specificity,
R2 is one of the more tractable mobile elements to study and, thus, is now among the best …
R2 is one of the more tractable mobile elements to study and, thus, is now among the best …
Site‐specific non‐LTR retrotransposons
H Fujiwara - Mobile DNA III, 2015 - Wiley Online Library
DNA transposons are the mobile elements that move by a “cut and paste” mechanism (1, 2).
In contrast, retrotransposons encode reverse transcriptase, and move by a “copy and paste” …
In contrast, retrotransposons encode reverse transcriptase, and move by a “copy and paste” …
Molecular Pathways and Pigments Underlying the Colors of the Pearl Oyster Pinctada margaritifera var. cumingii (Linnaeus 1758)
PL Stenger, CL Ky, C Reisser, J Duboisset, H Dicko… - Genes, 2021 - mdpi.com
The shell color of the Mollusca has attracted naturalists and collectors for hundreds of years,
while the molecular pathways regulating pigment production and the pigments themselves …
while the molecular pathways regulating pigment production and the pigments themselves …
Conserved and divergent DNA recognition specificities and functions of R2 retrotransposon N-terminal domains
RJ Lee, CA Horton, B Van Treeck, JJR McIntyre… - Cell Reports, 2024 - cell.com
R2 non-long terminal repeat (non-LTR) retrotransposons are among the most extensively
distributed mobile genetic elements in multicellular eukaryotes and show promise for …
distributed mobile genetic elements in multicellular eukaryotes and show promise for …
Endonuclease domain of non-LTR retrotransposons: loss-of-function mutants and modeling of the R2Bm endonuclease
A Govindaraju, JD Cortez, B Reveal… - Nucleic acids …, 2016 - academic.oup.com
Non-LTR retrotransposons are an important class of mobile elements that insert into host
DNA by target-primed reverse transcription (TPRT). Non-LTR retrotransposons must bind to …
DNA by target-primed reverse transcription (TPRT). Non-LTR retrotransposons must bind to …
Globular domain structure and function of restriction-like-endonuclease LINEs: similarities to eukaryotic splicing factor Prp8
Background R2 elements are a clade of early branching Long Interspersed Elements
(LINEs). LINEs are retrotransposable elements whose replication can have profound effects …
(LINEs). LINEs are retrotransposable elements whose replication can have profound effects …
A Survey of Transposon Landscapes in the Putative Ancient Asexual Ostracod Darwinula stevensoni
How asexual reproduction shapes transposable element (TE) content and diversity in
eukaryotic genomes remains debated. We performed an initial survey of TE load and …
eukaryotic genomes remains debated. We performed an initial survey of TE load and …
The linker region of LINEs modulates DNA cleavage and DNA polymerization
M Pradhan, A Govindaraju, A Jagdish… - Analytical …, 2020 - Elsevier
Long interspersed elements (LINEs) replicate by target primed reverse transcription (TPRT).
Insertion involves two half reactions. Each half reaction involves DNA cleavage followed by …
Insertion involves two half reactions. Each half reaction involves DNA cleavage followed by …