Modeling neoplastic disease with spheroids and organoids
Cancer is a complex disease in which both genetic defects and microenvironmental
components contribute to the development, progression, and metastasization of disease …
components contribute to the development, progression, and metastasization of disease …
Hydrogel microenvironments for cancer spheroid growth and drug screening
Y Li, E Kumacheva - Science advances, 2018 - science.org
Multicellular cancer spheroids (MCSs) have emerged as a promising in vitro model that
replicates many features of solid tumors in vivo. Biomimetic hydrogel scaffolds for MCS …
replicates many features of solid tumors in vivo. Biomimetic hydrogel scaffolds for MCS …
[HTML][HTML] Multicellular spheroid based on a triple co-culture: A novel 3D model to mimic pancreatic tumor complexity
G Lazzari, V Nicolas, M Matsusaki, M Akashi… - Acta biomaterialia, 2018 - Elsevier
The preclinical drug screening of pancreatic cancer treatments suffers from the absence of
appropriate models capable to reproduce in vitro the heterogeneous tumor …
appropriate models capable to reproduce in vitro the heterogeneous tumor …
Anticancer drug discovery using multicellular tumor spheroid models
Introduction: Despite the increasing financial outlay on cancer research and drug discovery,
many advanced cancers remain incurable. One possible strategy for increasing the approval …
many advanced cancers remain incurable. One possible strategy for increasing the approval …
Biomimetic tumor microenvironments based on collagen matrices
The extracellular matrix (ECM) establishes the basis for the cell's microenvironment
providing structural and mechanical support to cells and tissues, and regulating multiple cell …
providing structural and mechanical support to cells and tissues, and regulating multiple cell …
The current landscape of 3D in vitro tumor models: what cancer hallmarks are accessible for drug discovery?
D Rodenhizer, T Dean, E D'Arcangelo… - Advanced …, 2018 - Wiley Online Library
Cancer prognosis remains a lottery dependent on cancer type, disease stage at diagnosis,
and personal genetics. While investment in research is at an all‐time high, new drugs are …
and personal genetics. While investment in research is at an all‐time high, new drugs are …
Harnessing three-dimensional (3D) cell culture models for pulmonary infections: State of the art and future directions
DD Shah, NR Raghani, MR Chorawala, S Singh… - Naunyn-Schmiedeberg's …, 2023 - Springer
Pulmonary infections have been a leading etiology of morbidity and mortality worldwide.
Upper and lower respiratory tract infections have multifactorial causes, which include …
Upper and lower respiratory tract infections have multifactorial causes, which include …
Transcending toward advanced 3D-cell culture modalities: a review about an emerging paradigm in translational oncology
J Farhat, I Pandey, M AlWahsh - Cells, 2021 - mdpi.com
Cancer is a disorder characterized by an uncontrollable overgrowth and a fast-moving
spread of cells from a localized tissue to multiple organs of the body, reaching a metastatic …
spread of cells from a localized tissue to multiple organs of the body, reaching a metastatic …
Choosing wisely–Preclinical test models in the era of precision medicine
K Klinghammer, W Walther, J Hoffmann - Cancer treatment reviews, 2017 - Elsevier
Through the introduction of a steadily growing variety of preclinical test models drug
development and biomarker research has advanced. Next to classical used 2D cell line …
development and biomarker research has advanced. Next to classical used 2D cell line …
[HTML][HTML] Tumor Spheroids as Model to Design Acoustically Mediated Drug Therapies: A Review
M Roy, C Alix, A Bouakaz, S Serrière, JM Escoffre - Pharmaceutics, 2023 - mdpi.com
Tumor spheroids as well as multicellular tumor spheroids (MCTSs) are promising 3D in vitro
tumor models for drug screening, drug design, drug targeting, drug toxicity, and validation of …
tumor models for drug screening, drug design, drug targeting, drug toxicity, and validation of …