Cancer is a complex disease in which both genetic defects and microenvironmental
components contribute to the development, progression, and metastasization of disease …

Multicellular cancer spheroids (MCSs) have emerged as a promising in vitro model that
replicates many features of solid tumors in vivo. Biomimetic hydrogel scaffolds for MCS …

The preclinical drug screening of pancreatic cancer treatments suffers from the absence of
appropriate models capable to reproduce in vitro the heterogeneous tumor …

Introduction: Despite the increasing financial outlay on cancer research and drug discovery,
many advanced cancers remain incurable. One possible strategy for increasing the approval …

The extracellular matrix (ECM) establishes the basis for the cell's microenvironment
providing structural and mechanical support to cells and tissues, and regulating multiple cell …

Cancer prognosis remains a lottery dependent on cancer type, disease stage at diagnosis,
and personal genetics. While investment in research is at an all‐time high, new drugs are …

Pulmonary infections have been a leading etiology of morbidity and mortality worldwide.
Upper and lower respiratory tract infections have multifactorial causes, which include …

Cancer is a disorder characterized by an uncontrollable overgrowth and a fast-moving
spread of cells from a localized tissue to multiple organs of the body, reaching a metastatic …

Through the introduction of a steadily growing variety of preclinical test models drug
development and biomarker research has advanced. Next to classical used 2D cell line …

Tumor spheroids as well as multicellular tumor spheroids (MCTSs) are promising 3D in vitro
tumor models for drug screening, drug design, drug targeting, drug toxicity, and validation of …