For many thousands of years, the sun was our only source of light, and human behavior
followed a natural day-night cycle. This milieu began to change approximately 150 years …

The impact of circadian rhythms on cardiovascular function and disease development is well
established, with numerous studies in genetically modified animals emphasizing the …

Disruption of peripheral circadian rhyme pathways dominantly leads to metabolic disorders.
Studies on circadian rhythm proteins in the heart indicated a role for Clock or Per2 in cardiac …

Myocardial ischemia-reperfusion injury (MIRI), the joint result of ischemic injury and
reperfusion injury, is associated with poor outcomes in patients with acute myocardial …

The rotation of the earth and associated alternating cycles of light and dark—the basis of our
circadian rhythms—are fundamental to human biology and culture. However, it was not until …

The circadian rhythm regulates various physiological mechanisms, and its disruption can
promote many disorders. Disturbance of endogenous circadian rhythms enhances the …

A wide search for ischemic preconditioning (IPC) mechanisms of cardioprotection identified
the light elicited circadian rhythm protein Period 2 (Per2) to be cardioprotective. Studies on …

Circadian rhythms are essential to physiological homeostasis, but often disrupted in the
intensive care unit (ICU) due to the absence of natural zeitgebers and exposure to …

Disruption of endogenous circadian rhythms has been shown to increase the risk of
developing myocardial infarction (MI), suggesting that circadian genes might play a role in …

Aim Estrogen (E2) confers cardioprotection in premenopausal women and in models of
menopause and its effects, mostly studied in female reproductive organs, vary on a circadian …