Inhibition of microRNA function by antimiR oligonucleotides
MicroRNAs (miRNAs) have emerged as important post-transcriptional regulators of gene
expression in many developmental and cellular processes. Moreover, there is now ample …
expression in many developmental and cellular processes. Moreover, there is now ample …
[HTML][HTML] Locked nucleic acid: modality, diversity, and drug discovery
PH Hagedorn, R Persson, ED Funder, N Albæk… - Drug Discovery …, 2018 - Elsevier
Highlights•Locked nucleic acid-modified antisense oligonucleotides (LNAs) bind to and
modulate RNA.•The high binding affinity of LNAs significantly improves potency.•Structural …
modulate RNA.•The high binding affinity of LNAs significantly improves potency.•Structural …
Sensitive and specific detection of microRNAs by northern blot analysis using LNA-modified oligonucleotide probes
We describe here a new method for highly efficient detection of microRNAs by northern blot
analysis using LNA (locked nucleic acid)-modified oligonucleotides. In order to exploit the …
analysis using LNA (locked nucleic acid)-modified oligonucleotides. In order to exploit the …
LNA (locked nucleic acid): high-affinity targeting of complementary RNA and DNA
B Vester, J Wengel - Biochemistry, 2004 - ACS Publications
Locked nucleic acid (LNA) is a nucleic acid analogue containing one or more LNA
nucleotide monomers with a bicyclic furanose unit locked in an RNA mimicking sugar …
nucleotide monomers with a bicyclic furanose unit locked in an RNA mimicking sugar …
Locked vs. unlocked nucleic acids (LNA vs. UNA): contrasting structures work towards common therapeutic goals
MA Campbell, J Wengel - Chemical Society Reviews, 2011 - pubs.rsc.org
Oligonucleotide chemistry has been developed greatly over the past three decades, with
many advances in increasing nuclease resistance, enhancing duplex stability and assisting …
many advances in increasing nuclease resistance, enhancing duplex stability and assisting …
The structural diversity of artificial genetic polymers
Synthetic genetics is a subdiscipline of synthetic biology that aims to develop artificial
genetic polymers (also referred to as xeno-nucleic acids or XNAs) that can replicate in vitro …
genetic polymers (also referred to as xeno-nucleic acids or XNAs) that can replicate in vitro …
Locked nucleic acids: promising nucleic acid analogs for therapeutic applications
Abstract Locked Nucleic Acid (LNA) is a unique nucleic‐acid modification possessing very
high binding affinity and excellent specificity toward complementary RNA or DNA …
high binding affinity and excellent specificity toward complementary RNA or DNA …
An overview of sugar‐modified oligonucleotides for antisense therapeutics
TP Prakash - Chemistry & biodiversity, 2011 - Wiley Online Library
Among the multitude of chemical modifications that have been described over the past two
decades, oligonucleotide analogs that are modified at the 2′‐position of the furanose sugar …
decades, oligonucleotide analogs that are modified at the 2′‐position of the furanose sugar …
Perspectives on chemistry and therapeutic applications of Locked Nucleic Acid (LNA)
H Kaur, BR Babu, S Maiti - Chemical Reviews, 2007 - ACS Publications
This review focuses on the potentials and perspectives of Locked Nucleic Acid (LNA)-based
oligonucleotides as therapeutic candidates. It briefly outlines various oligonucleotide-based …
oligonucleotides as therapeutic candidates. It briefly outlines various oligonucleotide-based …
Stability and mismatch discrimination of locked nucleic acid–DNA duplexes
R Owczarzy, Y You, CL Groth, AV Tataurov - Biochemistry, 2011 - ACS Publications
Locked nucleic acids (LNA; symbols of bases,+ A,+ C,+ G, and+ T) are introduced into
chemically synthesized oligonucleotides to increase duplex stability and specificity. To …
chemically synthesized oligonucleotides to increase duplex stability and specificity. To …