MicroRNAs (miRNAs) have emerged as important post-transcriptional regulators of gene
expression in many developmental and cellular processes. Moreover, there is now ample …

Highlights•Locked nucleic acid-modified antisense oligonucleotides (LNAs) bind to and
modulate RNA.•The high binding affinity of LNAs significantly improves potency.•Structural …

We describe here a new method for highly efficient detection of microRNAs by northern blot
analysis using LNA (locked nucleic acid)-modified oligonucleotides. In order to exploit the …

Locked nucleic acid (LNA) is a nucleic acid analogue containing one or more LNA
nucleotide monomers with a bicyclic furanose unit locked in an RNA mimicking sugar …

Oligonucleotide chemistry has been developed greatly over the past three decades, with
many advances in increasing nuclease resistance, enhancing duplex stability and assisting …

Synthetic genetics is a subdiscipline of synthetic biology that aims to develop artificial
genetic polymers (also referred to as xeno-nucleic acids or XNAs) that can replicate in vitro …

Abstract Locked Nucleic Acid (LNA) is a unique nucleic‐acid modification possessing very
high binding affinity and excellent specificity toward complementary RNA or DNA …

Among the multitude of chemical modifications that have been described over the past two
decades, oligonucleotide analogs that are modified at the 2′‐position of the furanose sugar …

This review focuses on the potentials and perspectives of Locked Nucleic Acid (LNA)-based
oligonucleotides as therapeutic candidates. It briefly outlines various oligonucleotide-based …

Locked nucleic acids (LNA; symbols of bases,+ A,+ C,+ G, and+ T) are introduced into
chemically synthesized oligonucleotides to increase duplex stability and specificity. To …