Therapeutic strategies for COVID-19: progress and lessons learned
G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases
G Wigerblad, MJ Kaplan - Nature Reviews Immunology, 2023 - nature.com
Systemic autoimmune diseases are characterized by the failure of the immune system to
differentiate self from non-self. These conditions are associated with significant morbidity …
differentiate self from non-self. These conditions are associated with significant morbidity …
Applications of single-cell RNA sequencing in drug discovery and development
B Van de Sande, JS Lee, E Mutasa-Gottgens… - Nature Reviews Drug …, 2023 - nature.com
Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods,
together with associated computational tools and the growing availability of public data …
together with associated computational tools and the growing availability of public data …
Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis
AJ Kwok, A Allcock, RC Ferreira, E Cano-Gamez… - Nature …, 2023 - nature.com
Sepsis arises from diverse and incompletely understood dysregulated host response
processes following infection that leads to life-threatening organ dysfunction. Here we …
processes following infection that leads to life-threatening organ dysfunction. Here we …
Inhalation delivery of dexamethasone with iSEND nanoparticles attenuates the COVID-19 cytokine storm in mice and nonhuman primates
QF Meng, W Tai, M Tian, X Zhuang, Y Pan, J Lai… - Science …, 2023 - science.org
Dexamethasone (DEX) is the first drug to show life-saving efficacy in patients with severe
coronavirus disease 2019 (COVID-19), while DEX is associated with serious adverse …
coronavirus disease 2019 (COVID-19), while DEX is associated with serious adverse …
Recent developments in the immunopathology of COVID‐19
There has been an important change in the clinical characteristics and immune profile of
Coronavirus disease 2019 (COVID‐19) patients during the pandemic thanks to the …
Coronavirus disease 2019 (COVID‐19) patients during the pandemic thanks to the …
Respiratory sequelae of COVID-19: pulmonary and extrapulmonary origins, and approaches to clinical care and rehabilitation
Although the exact prevalence of post-COVID-19 condition (also known as long COVID) is
unknown, more than a third of patients with COVID-19 develop symptoms that persist for …
unknown, more than a third of patients with COVID-19 develop symptoms that persist for …
Dysbiosis of a microbiota–immune metasystem in critical illness is associated with nosocomial infections
Critically ill patients in intensive care units experience profound alterations of their gut
microbiota that have been linked to a high risk of hospital-acquired (nosocomial) infections …
microbiota that have been linked to a high risk of hospital-acquired (nosocomial) infections …
Immune mechanisms underlying COVID-19 pathology and post-acute sequelae of SARS-CoV-2 infection (PASC)
With a global tally of more than 500 million cases of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infections to date, there are growing concerns about the post …
coronavirus 2 (SARS-CoV-2) infections to date, there are growing concerns about the post …
Origin and heterogeneity of tissue myeloid cells: a focus on GMP-derived monocytes and neutrophils
Myeloid cells are a significant proportion of leukocytes within tissues, comprising
granulocytes, monocytes, dendritic cells, and macrophages. With the identification of various …
granulocytes, monocytes, dendritic cells, and macrophages. With the identification of various …