Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …

Cancer cells support their growth and proliferation by reprogramming their metabolism in
order to gain access to nutrients. Despite the heterogeneity in genetic mutations that lead to …

Abstract The mTOR complex 1 (mTORC1) kinase nucleates a pathway that promotes cell
growth and proliferation and is the target of rapamycin, a drug with many clinical uses …

The mammalian target of rapamycin (mTOR) kinase is a master regulator of protein
synthesis that couples nutrient sensing to cell growth and cancer. However, the downstream …

Aberrant activation of the mammalian target of rapamycin complex 1 (mTORC1) is a
common molecular event in a variety of pathological settings, including genetic tumor …

Cellular states are determined by differential expression of the cell's proteins. The
relationship between protein and mRNA expression levels informs about the combined …

Elevated protein synthesis is an important feature of many cancer cells and often arises as a
consequence of increased signaling flux channeled to eukaryotic initiation factor 4F (eIF4F) …

Abstract Indoleamine 2, 3-dioxygenase (IDO) is an enzyme that degrades the essential
amino acid tryptophan. The concept that cells expressing IDO can suppress T-cell …

The target of rapamycin (TOR) pathway is a major nutrient-sensing pathway that, when
genetically downregulated, increases life span in evolutionarily diverse organisms including …

Long-lasting forms of synaptic plasticity and memory are dependent on new protein
synthesis. Recent advances obtained from genetic, physiological, pharmacological, and …