Background: Acromegaly is characterized by impaired bone quality and increased fracture
risk. However, due to the pathophysiology of acromegalic osteopathy, bone mineral density …

Growth hormone (GH) and insulin-like growth factor-I (IGF-I) exert physiological actions on
the skeleton throughout life, by stimulating longitudinal bone growth in children, the …

Abstract Purpose Vertebral fractures (VFs) are a potential complication in acromegaly.
However, the etiology of this skeletal fragility is unknown. This review aimed to evaluate the …

Context Acromegaly can impair bone integrity, increasing the risk of vertebral fractures
(VFs). Objective To evaluate the impact of isolated GH/IGF-I hypersecretion on bone …

Context: Acromegaly has been associated with calcium-phosphate and bone turnover
alterations. Controlled studies of these interactions are sparse. Objective: To evaluate …

Although GH and IGF-1 excess has a controversial impact on bone mineral density (BMD),
acromegalic patients display variable degrees of bone structure impairment. In this study, we …

Background Biochemical control of GH/IGF-I excess in acromegaly (ACRO) is associated
with persistent impairment of trabecular microstructure leading to increased risk of vertebral …

Trabecular bone score (TBS) index has recently been obtained as a result of textural
greyscale analysis of DXA images. Because it enables the assessment of bone …

Background Statins reduce cardiovascular events and may improve bone mineral density.
Methods We conducted a sub-analysis of a randomized clinical trial that investigated the …

Abstract Objective The Wnt signaling pathway is an important modulator of bone
metabolism. This study aims to clarify the changes in Wnt antagonists in active and …