Role of gut microbiota-generated short-chain fatty acids in metabolic and cardiovascular health

ES Chambers, T Preston, G Frost, DJ Morrison - Current nutrition reports, 2018 - Springer
Abstract Purpose of this Review This review assesses the latest evidence linking short-chain
fatty acids (SCFA) with host metabolic health and cardiovascular disease (CVD) risk and …

Butyrate in energy metabolism: there is still more to learn

L Zhang, C Liu, Q Jiang, Y Yin - Trends in Endocrinology & Metabolism, 2021 - cell.com
Butyrate, a main product of gut microbial fermentation, has been recognized as an important
mediator of gut microbiota regulation in whole body energy homeostasis. However, the …

The protective role of butyrate against obesity and obesity-related diseases

S Coppola, C Avagliano, A Calignano, R Berni Canani - Molecules, 2021 - mdpi.com
Worldwide obesity is a public health concern that has reached pandemic levels. Obesity is
the major predisposing factor to comorbidities, including type 2 diabetes, cardiovascular …

Short-chain fatty acids as potential regulators of skeletal muscle metabolism and function

J Frampton, KG Murphy, G Frost, ES Chambers - Nature metabolism, 2020 - nature.com
A key metabolic activity of the gut microbiota is the fermentation of non-digestible
carbohydrate, which generates short-chain fatty acids (SCFAs) as the principal end …

Nondigestible carbohydrates, butyrate, and butyrate-producing bacteria

X Fu, Z Liu, C Zhu, H Mou, Q Kong - Critical reviews in food science …, 2019 - Taylor & Francis
Nondigestible carbohydrates (NDCs) are fermentation substrates in the colon after escaping
digestion in the upper gastrointestinal tract. Among NDCs, resistant starch is not hydrolyzed …

Short chain fatty acids in the colon and peripheral tissues: a focus on butyrate, colon cancer, obesity and insulin resistance

SM McNabney, TM Henagan - Nutrients, 2017 - mdpi.com
Increased dietary fiber consumption has been associated with many beneficial effects,
including amelioration of obesity and insulin resistance. These effects may be due to the …

Gut dysbiosis is linked to hypertension

T Yang, MM Santisteban, V Rodriguez, E Li… - …, 2015 - Am Heart Assoc
Emerging evidence suggests that gut microbiota is critical in the maintenance of
physiological homeostasis. This study was designed to test the hypothesis that dysbiosis in …

Butyrate to combat obesity and obesity‐associated metabolic disorders: Current status and future implications for therapeutic use

T van Deuren, EE Blaak, EE Canfora - Obesity Reviews, 2022 - Wiley Online Library
Evidence is increasing that disturbances in the gut microbiome may play a significant role in
the etiology of obesity and type 2 diabetes. The short chain fatty acid butyrate, a major end …

[HTML][HTML] The role of short chain fatty acids in inflammation and body health

Y Du, C He, Y An, Y Huang, H Zhang, W Fu… - International journal of …, 2024 - mdpi.com
Short chain fatty acids (SCFAs), mainly including acetate, propionate and butyrate, are
produced by intestinal bacteria during the fermentation of partially digested and indigestible …

[HTML][HTML] Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier

DA Zhou, Q Pan, FZ Xin, RN Zhang, CX He… - World journal of …, 2017 - ncbi.nlm.nih.gov
AIM To investigate whether gut microbiota metabolite sodium butyrate (NaB) is an effective
substance for attenuating non-alcoholic fatty liver disease (NAFLD) and the internal …