Efficacy and safety of intravitreal anti-VEGF therapy in diabetic retinopathy: what we have learned and what should we learn further?

G Uludag, M Hassan, W Matsumiya… - Expert opinion on …, 2022 - Taylor & Francis
Introduction Diabetic retinopathy (DR) is one of the most frequent microvascular
complications of diabetes that can lead to blindness. Laser treatment has been the gold …

Cardiovascular adverse events with intravitreal anti–vascular endothelial growth factor drugs: a systematic review and meta-analysis of randomized clinical trials

NN Ntjam, M Thulliez, G Paintaud, F Salvo… - JAMA …, 2021 - jamanetwork.com
Importance Systemic safety of intravitreal anti-vascular endothelial growth factor (anti-VEGF)
is a matter of debate and regular updates are necessary. Objective To evaluate systemic …

[HTML][HTML] A real-world study of effectiveness of intravitreal bevacizumab and ranibizumab injection for treating retinal diseases in Thailand

S Kumluang, L Ingsrisawang, S Sangroongruangsri… - BMC …, 2019 - Springer
Background To evaluate the effectiveness of intravitreal bevacizumab (IVB) and intravitreal
ranibizumab (IVR) in actual practice for treating patients with retinal diseases in Thailand …

[HTML][HTML] Intravitreal vascular endothelial growth factor inhibitor use and renal function decline in patients with diabetic retinopathy

SH Ou, CH Yin, TL Chung, HY Chen, CL Chen… - International Journal of …, 2022 - mdpi.com
Adverse renal effects of systemic vascular endothelial growth factor (VEGF) inhibitor
treatment are well documented. We aimed to identify associations between intravitreal VEGF …

[HTML][HTML] Bevacizumab for eye diseases–Legal, regulatory, and ethical overview

V Jose, S Radhakrishna, P Pipalava… - Indian journal of …, 2019 - journals.lww.com
Vascular endothelial growth factor (VEGF) inhibitors, ranibizumab, aflibercept, and
pegaptanib are approved treatments for certain eye diseases that occurs especially in the …

Cardiovascular risk in patients receiving ranibizumab for exudative age-related macular degeneration: a nationwide self-controlled case-series study

HL Jeon, SJ Byun, NL Pratt, J Sultana… - British Journal of …, 2021 - bjo.bmj.com
Aims To identify the association between ranibizumab and risk of stroke and acute
myocardial infarction (AMI) in patients with exudative age-related macular degeneration …

Systemic thromboembolic adverse events in patients treated with intravitreal anti-VEGF drugs for neovascular age-related macular degeneration: an update

C Costagliola, F Morescalchi, S Duse… - Expert opinion on …, 2019 - Taylor & Francis
Introduction: Intravitreal anti-VEGF is the most effective therapy for wet AMD, although
systemic effects on the endothelium cannot be excluded. Areas covered: The purpose of this …

[HTML][HTML] The Association of Intravitreal Injections of Different Anti-Vascular Endothelial Growth Factor with Systemic Outcomes in Diabetic Patients

EYC Kang, TY Lin, SJ Garg, NK Wang, LJ Chen… - Journal of Personalized …, 2023 - mdpi.com
This retrospective cohort study aimed to assess the systemic effects of three commonly
available anti-vascular endothelial growth factor intravitreal injections in patients with …

Increased mortality after intravitreal injections of anti-VEGF for neovascular AMD among patients with prior stroke or acute myocardial infarction

YY Chen, YJ Lai, YF Yen, P Chou - Eye, 2022 - nature.com
Objectives To evaluate whether intravitreal injections (IVI) of anti-vascular endothelial
growth factor (anti-VEGF) in neovascular age-related macular degeneration (nAMD) patients …

Real-world data and real-world evidence

X Sun - Advanced Statistics in Regulatory Critical Clinical …, 2022 - taylorfrancis.com
Real-World Data (RWD) is commonly defined as data collected in a non-randomized
controlled trial setting, highlighting the representativeness of RWD for an actual diagnosis …