Many applications in computational physics involve approximating problems with
microstructure, characterized by multiple spatial scales in their data. However, these …

Hypoxia contributes significantly to resistance in radiotherapy. Our research rigorously
examines the influence of microvascular morphology on radiotherapy outcome, specifically …

Forward uncertainty quantification (UQ) for partial differential equations is a many-query task
that requires a significant number of model evaluations. The objective of this work is to …

Radiotherapy consists in delivering a precise radiation dose to a specific tumor target in
order to eradicate tumor cells and to achieve local tumor control. The definition of the most …

Radiotherapy (RT) is the most common cancer treatment, and hypoxia is one of the main
causes of resistance to RT. We investigate how microvascular morphology affects radiation …

Microvasculature plays a crucial role in the microenvironment, providing nutrients/drugs, and
facilitating the trafficking of immune cells. In previous studies, degraded microvascular …

This study tackles the main challenge of numerically solving multiscale problems, which
arises from the complexity involved in discretizing, assembling, and solving the multiscale …

Oncology stands out as one of the most research-intensive fields, with the goal of
developing increasingly effective treatments with fewer side effects. However, the process of …