Summary Lung cancer in East Asia is characterized by a high percentage of never-smokers,
early onset and predominant EGFR mutations. To illuminate the molecular phenotype of this …

Molecular glue compounds induce protein–protein interactions that, in the context of a
ubiquitin ligase, lead to protein degradation. Unlike traditional enzyme inhibitors, these …

Gene expression is regulated by promoters and enhancers marked by histone H3 lysine 27
acetylation (H3K27ac), which is established by the paralogous histone acetyltransferases …

Cell lines are commonly used as cancer models. The tissue of origin provides context for
understanding biological mechanisms and predicting therapy response. We therefore …

Aberrant sialylation plays a key biological role in tumorigenesis and metastasis, including
tumor cell survival and invasion, immune evasion, angiogenesis, and resistance to therapy …

Objectives This study aimed to examine the extent of community pharmacists' awareness of
Chat Generative Pretraining Transformer (ChatGPT), their willingness to embark on this new …

Lung cancer is the leading cause of cancer-related deaths worldwide. The paralogous
transcriptional cofactors Yes-associated protein (YAP) and transcriptional coactivator with …

In their recent paper,[1] Lamballe et al. identify the combination treatment with BCL-XL and
WEE1 inhibitors as a promising therapeutic approach in triple-negative breast cancer …

Background: Large-scale loss-of-function screening database such as Cancer Dependency
Map (Depmap) provide abundant resources. Investigation of these potential dependency …

Background The heterogeneity of bladder cancers (BCs) is a major challenge for the
development of novel therapies. However, given the high rates of recurrence and/or …