Animal models for COVID-19: advances, gaps and perspectives

C Fan, Y Wu, X Rui, Y Yang, C Ling, S Liu… - Signal transduction and …, 2022 - nature.com
Abstract COVID-19, caused by SARS-CoV-2, is the most consequential pandemic of this
century. Since the outbreak in late 2019, animal models have been playing crucial roles in …

SARS-CoV-2 Omicron variant causes mild pathology in the upper and lower respiratory tract of hamsters

F Armando, G Beythien, FK Kaiser, L Allnoch… - Nature …, 2022 - nature.com
Since its discovery in 2019, multiple variants of severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2) have been identified. This study investigates virus spread and …

[PDF][PDF] Geroscience and pathology: a new frontier in understanding age-related diseases

M Fekete, D Major, A Feher… - Pathology and …, 2024 - por-journal.com
Geroscience, an emerging discipline at the intersection of aging and disease, seeks to
understand the relationship between the aging process and pathogenesis of age-related …

A bacterial extracellular vesicle‐based intranasal vaccine against SARS‐CoV‐2 protects against disease and elicits neutralizing antibodies to wild‐type and Delta …

L Jiang, TAP Driedonks, WSP Jong… - Journal of …, 2022 - Wiley Online Library
Several vaccines have been introduced to combat the coronavirus infectious disease‐2019
(COVID‐19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS …

Hamster model for post-COVID-19 alveolar regeneration offers an opportunity to understand post-acute sequelae of SARS-CoV-2

L Heydemann, M Ciurkiewicz, G Beythien… - Nature …, 2023 - nature.com
COVID-19 survivors often suffer from post-acute sequelae of SARS-CoV-2 infection (PASC).
Current evidence suggests dysregulated alveolar regeneration as a possible explanation for …

SARS-CoV-2 enters human leydig cells and affects Testosterone Production in Vitro

L Li, CM Sottas, HY Chen, Y Li, H Cui, JS Villano… - Cells, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a SARS-like coronavirus,
continues to produce mounting infections and fatalities all over the world. Recent data point …

Development of Monoclonal Antibody 281-mG2a-f Against Golden Hamster Podoplanin

R Nanamiya, H Suzuki, J Takei, G Li… - Monoclonal …, 2022 - liebertpub.com
Golden (Syrian) hamster (Mesocricetus auratus) is a small animal model of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Pathological analyses of the …

Multivalent IgM scaffold enhances the therapeutic potential of variant-agnostic ACE2 decoys against SARS-CoV-2

MM Verstraete, F Heinkel, J Li, S Cao, A Tran… - MAbs, 2023 - Taylor & Francis
As immunological selection for escape mutants continues to give rise to future SARS-CoV-2
variants, novel universal therapeutic strategies against ACE2-dependent viruses are …

Two DNA vaccines protect against severe disease and pathology due to SARS-CoV-2 in Syrian hamsters

GG Babuadze, H Fausther-Bovendo, MA Delavega… - npj Vaccines, 2022 - nature.com
The SARS-CoV-2 pandemic is an ongoing threat to global health, and wide-scale
vaccination is an efficient method to reduce morbidity and mortality. We designed and …

SARS-CoV-2 variant Pathogenesis following primary infection and reinfection in Syrian hamsters

J Plunkard, K Mulka, R Zhou, P Tarwater, W Zhong… - Mbio, 2023 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
COVID-19, has evolved into multiple variants. Animal models are important to understand …