Mitochondria are crucial bioenergetics powerhouses and biosynthetic hubs within cells,
which can generate and sequester toxic reactive oxygen species (ROS) in response to …

Interleukin 11 (IL11) is an elusive member of the IL6 family of cytokines. While initially
thought to be a haematopoietic and cytoprotective factor, more recent data show instead that …

Translated small open reading frames (smORFs) can have important regulatory roles and
encode microproteins, yet their genome-wide identification has been challenging. We …

The kidney has large regenerative capacity, but this is compromised when kidney damage is
excessive and renal tubular epithelial cells (TECs) undergo SNAI1-driven growth arrest …

Renal fibrosis induced by urinary tract obstruction is a common clinical occurrence;
however, effective treatment is lacking, and a deeper understanding of the mechanism of …

Interleukin 11 (IL11) is upregulated in inflammatory conditions, where it is mostly believed to
have anti-inflammatory activity. However, recent studies suggest instead that IL11 promotes …

Objectives Giant cell arteritis (GCA) is a complex systemic vasculitis mediated by the
interplay between both genetic and epigenetic factors. Monocytes are crucial players of the …

In fibroblasts, TGFβ1 stimulates IL11 upregulation that leads to an autocrine loop of IL11-
dependent pro-fibrotic protein translation. The signaling pathways downstream of IL11 …

Background Pulmonary hypertension (PH) associated to idiopathic pulmonary fibrosis (IPF)
portends a poor prognosis. IL-11 has been implicated in fibrotic diseases, but their role on …

Vascular smooth muscle cell (VSMC) phenotypic switch plays an essential role in the
pathogenesis of hypertension. Mitochondrial dynamics, such as mitochondrial fission, can …