Mass spectrometry-based structural virology
Here we review recent developments in mass spectrometry that have enabled its growing
contribution to the field of structural virology. Evidently, there is a strong renewed general …
contribution to the field of structural virology. Evidently, there is a strong renewed general …
Alphavirus RNA replication in vertebrate cells
T Ahola, G McInerney, A Merits - Advances in virus research, 2021 - Elsevier
Alphaviruses are positive-strand RNA viruses, typically transmitted by mosquitoes between
vertebrate hosts. They encode four essential replication proteins, the non-structural proteins …
vertebrate hosts. They encode four essential replication proteins, the non-structural proteins …
Molecular architecture of the Chikungunya virus replication complex
To better understand how positive-strand (+) RNA viruses assemble membrane-associated
replication complexes (RCs) to synthesize, process, and transport viral RNA in virus-infected …
replication complexes (RCs) to synthesize, process, and transport viral RNA in virus-infected …
Structural insights into viral RNA capping and plasma membrane targeting by Chikungunya virus nonstructural protein 1
Chikungunya virus (CHIKV) causes a debilitating arthralgic inflammatory disease in
humans. The multifunctional CHIKV protein, nsP1, facilitates virus RNA replication and …
humans. The multifunctional CHIKV protein, nsP1, facilitates virus RNA replication and …
Architecture of the chikungunya virus replication organelle
T Laurent, P Kumar, S Liese, F Zare, M Jonasson… - Elife, 2022 - elifesciences.org
Alphaviruses are mosquito-borne viruses that cause serious disease in humans and other
mammals. Along with its mosquito vector, the Alphavirus chikungunya virus (CHIKV) has …
mammals. Along with its mosquito vector, the Alphavirus chikungunya virus (CHIKV) has …
Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold
Abstract Alphaviruses such as Ross River virus (RRV), chikungunya virus (CHIKV), Sindbis
virus (SINV), and Venezuelan equine encephalitis virus (VEEV) are mosquito-borne …
virus (SINV), and Venezuelan equine encephalitis virus (VEEV) are mosquito-borne …
De novo modelling of HEV replication polyprotein: Five-domain breakdown and involvement of flexibility in functional regulation
S Fieulaine, T Tubiana, S Bressanelli - Virology, 2023 - Elsevier
Hepatitis E virus (HEV), a major cause of acute viral hepatitis, is a single-stranded, positive-
sense RNA virus. As such, it encodes a 1700-residue replication polyprotein pORF1 that …
sense RNA virus. As such, it encodes a 1700-residue replication polyprotein pORF1 that …
The life cycle of the alphaviruses: From an antiviral perspective
AM Skidmore, SB Bradfute - Antiviral research, 2023 - Elsevier
The alphaviruses are a widely distributed group of positive-sense, single stranded, RNA
viruses. These viruses are largely arthropod-borne and can be found on all populated …
viruses. These viruses are largely arthropod-borne and can be found on all populated …
Subdomain cryo-EM structure of nodaviral replication protein A crown complex provides mechanistic insights into RNA genome replication
N Unchwaniwala, H Zhan… - Proceedings of the …, 2020 - National Acad Sciences
For positive-strand RNA [(+) RNA] viruses, the major target for antiviral therapies is genomic
RNA replication, which occurs at poorly understood membrane-bound viral RNA replication …
RNA replication, which occurs at poorly understood membrane-bound viral RNA replication …
Molecular basis of specific viral RNA recognition and 5′-end capping by the Chikungunya virus nsP1
Many viruses encode RNA-modifying enzymes to edit the 5′ end of viral RNA to mimic the
cellular mRNA for effective protein translation, genome replication, and evasion of the host …
cellular mRNA for effective protein translation, genome replication, and evasion of the host …