As an essential component of innate immunity, macrophages have multiple functions in both
inhibiting or promoting cell proliferation and tissue repair. Diversity and plasticity are …

LPS is a potent trigger of macrophage-mediated inflammation. However, prolonged
exposure to LPS induces a state of tolerance that reprograms the inflammatory response …

MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that can play critical
roles as regulators of numerous pathways and biological processes including the immune …

Chronic inflammation can drive tumor development. Here, we have identified microRNA-
146a (miR-146a) as a major negative regulator of colonic inflammation and associated …

Activation of inflammatory pathways in the endothelium contributes to vascular diseases,
including sepsis and atherosclerosis. We demonstrate that miR‐146a and miR‐146b are …

MicroRNA (miR)-155 is a critical player in both innate and adaptive immune responses. It
can influence CD4+ T cell lineage choice. To clarify the role of miR-155 in CD4+ CD25+ …

The ecosystem of the gut microbiota consists of diverse intestinal species with multiple
metabolic and immunologic activities and it is closely connected with the intestinal epithelia …

Toll-like receptors (TLRs) in innate immune cells are the prime cellular sensors for microbial
components. TLR activation leads to the production of proinflammatory mediators and thus …

MicroRNAs (miRNAs) are short single-stranded non-coding RNA sequences that
posttranscriptionally regulate up to 60% of protein encoding genes. Evidence is emerging …

Atherosclerosis is an inflammatory process due to oxidized low-density lipoprotein (oxLDL)
accumulation in macrophages. We investigated the involvement of microRNAs in oxLDL …