Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders
KJ Falkenberg, RW Johnstone - Nature reviews Drug discovery, 2014 - nature.com
Epigenetic aberrations, which are recognized as key drivers of several human diseases, are
often caused by genetic defects that result in functional deregulation of epigenetic proteins …
often caused by genetic defects that result in functional deregulation of epigenetic proteins …
Regulatory T cells in the treatment of disease
Regulatory T (Treg) cells suppress inflammation and regulate immune system activity. In
patients with systemic or organ-specific autoimmune diseases or those receiving …
patients with systemic or organ-specific autoimmune diseases or those receiving …
Foxp3 reprograms T cell metabolism to function in low-glucose, high-lactate environments
Immune cells function in diverse metabolic environments. Tissues with low glucose and high
lactate concentrations, such as the intestinal tract or ischemic tissues, frequently require …
lactate concentrations, such as the intestinal tract or ischemic tissues, frequently require …
Faecalibacterium prausnitzii Produces Butyrate to Maintain Th17/Treg Balance and to Ameliorate Colorectal Colitis by Inhibiting Histone Deacetylase 1
L Zhou, M Zhang, Y Wang, RG Dorfman… - Inflammatory bowel …, 2018 - academic.oup.com
Background Inflammatory bowel disease (IBD)–associated dysbiosis is characterized by a
loss of Faecalibacterium prausnitzii, whose supernatant exerts an anti-inflammatory effect …
loss of Faecalibacterium prausnitzii, whose supernatant exerts an anti-inflammatory effect …
Epigenetic protein families: a new frontier for drug discovery
Epigenetic regulation of gene expression is a dynamic and reversible process that
establishes normal cellular phenotypes but also contributes to human diseases. At the …
establishes normal cellular phenotypes but also contributes to human diseases. At the …
Structural insights into HDAC6 tubulin deacetylation and its selective inhibition
We report crystal structures of zebrafish histone deacetylase 6 (HDAC6) catalytic domains in
tandem or as single domains in complex with the (R) and (S) enantiomers of trichostatin A …
tandem or as single domains in complex with the (R) and (S) enantiomers of trichostatin A …
Therapeutic potential of targeting the Th17/Treg axis in autoimmune disorders
P Fasching, M Stradner, W Graninger, C Dejaco… - Molecules, 2017 - mdpi.com
A disruption of the crucial balance between regulatory T-cells (Tregs) and Th17-cells was
recently implicated in various autoimmune disorders. Tregs are responsible for the …
recently implicated in various autoimmune disorders. Tregs are responsible for the …
[HTML][HTML] The Hsp90 chaperone machinery: conformational dynamics and regulation by co-chaperones
Hsp90 is a dimeric molecular chaperone required for the activation and stabilization of
numerous client proteins many of which are involved in essential cellular processes like …
numerous client proteins many of which are involved in essential cellular processes like …
Histone deacetylases as regulators of inflammation and immunity
Histone deacetylases (HDACs) remove an acetyl group from lysine residues of target
proteins to regulate cellular processes. Small-molecule inhibitors of HDACs cause cellular …
proteins to regulate cellular processes. Small-molecule inhibitors of HDACs cause cellular …
Histone deacetylase 6 plays a role as a distinct regulator of diverse cellular processes
Y Li, D Shin, SH Kwon - The FEBS journal, 2013 - Wiley Online Library
Histone deacetylase (HDAC) 6 is the best‐characterized class II b deacetylase that
regulates many important biological processes via the formation of complexes with its …
regulates many important biological processes via the formation of complexes with its …