Synchronized SR calcium (Ca) release is critical to normal cardiac myocyte excitation-
contraction coupling, and ideally this release shuts off completely between heartbeats …

Cardiac output and rhythm depend on the release and the take‐up of calcium from the
sarcoplasmic reticulum (SR). Excessive diastolic calcium leak from the SR due to …

Oxidative stress may contribute to cardiac ryanodine receptor (RyR2) dysfunction in heart
failure (HF) and arrhythmias. Altered RyR2 domain–domain interaction (domain unzipping) …

Diastolic Ca 2+ leak due to cardiac ryanodine receptor (RyR2) hyperactivity has been widely
documented in chronic ischemic heart disease (CIHD) and may contribute to ventricular …

Background Dantrolene binds to the Leu 601-Cys 620 region of the N-terminal domain of
cardiac ryanodine receptor (RyR2), which corresponds to the Leu 590-Cys 609 region of the …

Rationale: Calmodulin (CaM) associates with cardiac ryanodine receptor type-2 (RyR2) as
an important regulator. Defective CaM–RyR2 interaction may occur in heart failure, cardiac …

Using time-resolved fluorescence resonance energy transfer (FRET), we have developed
and validated the first high-throughput screening (HTS) method to discover compounds that …

Diastolic calcium (Ca) leak via cardiac ryanodine receptors (RyR2) can cause arrhythmias
and heart failure (HF). Ca/calmodulin (CaM)-dependent kinase II (CaMKII) is upregulated …

The intracellular Ca 2+ sensor calmodulin (CaM) regulates the cardiac Ca 2+ release
channel/ryanodine receptor 2 (RyR2), and mutations in CaM cause arrhythmias such as …

Abstract Elevated cytoplasmic [Ca2+] is characteristic in severe skeletal and cardiac
myopathies, diabetes, and neurodegeneration, and partly results from increased Ca2+ leak …