Insulin and insulin resistance in Alzheimer's disease
A Sędzikowska, L Szablewski - International journal of molecular sciences, 2021 - mdpi.com
Insulin plays a range of roles as an anabolic hormone in peripheral tissues. It regulates
glucose metabolism, stimulates glucose transport into cells and suppresses hepatic glucose …
glucose metabolism, stimulates glucose transport into cells and suppresses hepatic glucose …
Altered glucose metabolism in Alzheimer's disease: role of mitochondrial dysfunction and oxidative stress
S Dewanjee, P Chakraborty, H Bhattacharya… - Free Radical Biology …, 2022 - Elsevier
Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …
Insulin resistance: Review of the underlying molecular mechanisms
Most human cells utilize glucose as the primary substrate, cellular uptake requiring insulin.
Insulin signaling is therefore critical for these tissues. However, decrease in insulin …
Insulin signaling is therefore critical for these tissues. However, decrease in insulin …
Diabetes mellitus and its metabolic complications: the role of adipose tissues
L Dilworth, A Facey, F Omoruyi - International journal of molecular …, 2021 - mdpi.com
Many approaches have been used in the effective management of type 2 diabetes mellitus.
A recent paradigm shift has focused on the role of adipose tissues in the development and …
A recent paradigm shift has focused on the role of adipose tissues in the development and …
Metformin improves mitochondrial respiratory activity through activation of AMPK
Impaired mitochondrial respiratory activity contributes to the development of insulin
resistance in type 2 diabetes. Metformin, a first-line antidiabetic drug, functions mainly by …
resistance in type 2 diabetes. Metformin, a first-line antidiabetic drug, functions mainly by …
[HTML][HTML] Diabetes mellitus: The epidemic of the century
AT Kharroubi, HM Darwish - World journal of diabetes, 2015 - ncbi.nlm.nih.gov
The epidemic nature of diabetes mellitus in different regions is reviewed. The Middle East
and North Africa region has the highest prevalence of diabetes in adults (10.9%) whereas …
and North Africa region has the highest prevalence of diabetes in adults (10.9%) whereas …
Insulin–PI3K signalling: an evolutionarily insulated metabolic driver of cancer
Cancer is driven by incremental changes that accumulate, eventually leading to oncogenic
transformation. Although genetic alterations dominate the way cancer biologists think about …
transformation. Although genetic alterations dominate the way cancer biologists think about …
Biomarkers of oxidative stress in metabolic syndrome and associated diseases
R Vona, L Gambardella, C Cittadini… - Oxidative medicine …, 2019 - Wiley Online Library
Metabolic syndrome (MS) represents worldwide public health issue characterized by a set of
cardiovascular risk factors including obesity, diabetes, dyslipidemia, hypertension, and …
cardiovascular risk factors including obesity, diabetes, dyslipidemia, hypertension, and …
[HTML][HTML] The brain as an insulin-sensitive metabolic organ
JL Milstein, HA Ferris - Molecular Metabolism, 2021 - Elsevier
Background The brain was once thought of as an insulin-insensitive organ. We now know
that the insulin receptor is present throughout the brain and serves important functions in …
that the insulin receptor is present throughout the brain and serves important functions in …
From OCR and ECAR to energy: Perspectives on the design and interpretation of bioenergetics studies
Biological energy transduction underlies all physiological phenomena in cells. The
metabolic systems that support energy transduction have been of great interest due to their …
metabolic systems that support energy transduction have been of great interest due to their …