Over the past decades, the bulk of chemists' interests have been on heterocyclic compounds
and their various derivatives as well as their applications in the pharmaceutical and …

The blood–brain barrier (BBB) is the interface between the central nervous system and
systemic circulation. It tightly regulates what enters and is removed from the brain …

Stroke disrupts the homeostatic balance within the brain and is associated with a significant
accumulation of necrotic cellular debris, fluid, and peripheral immune cells in the central …

Brain edema is a common feature of brain injuries, which leads to increased intracranial
pressure (ICP) and ischemia that worsen outcome. Current management of edema focuses …

Aquaporins (AQPs) are membrane channels that conduct water and small solutes such as
glycerol and are involved in many physiological functions. Aquaporin-based modulator …

Aquaporin-4 (AQP4) is the most abundant water channel in the brain, and its inhibition
before inducing focal ischemia, using the AQP4 inhibitor TGN-020, has been showed to …

Dysfunction of the aquaporin‐4 (AQP4)‐dependent glymphatic waste clearance pathway
has recently been implicated in the pathogenesis of several neurodegenerative diseases …

Identification of the aquaporin (AQP) protein family more than twenty years ago has ushered
in an era where water and neutral solute trafficking is considered a prime target for …

The glymphatic system transports cerebrospinal fluid (CSF) into the brain via arterial
perivascular spaces and removes interstitial fluid from the brain along perivenous spaces …

Aims Identifying drugs that inhibit edema and glial scar formation and increase neuronal
survival is crucial to improving outcomes after spinal cord injury (SCI). Here, we used 2 …