Depression is a common neuropsychiatric disorder characterized by persistent depressed
mood and causes serious socioeconomic burden worldwide. Hyperactivity of the …

Phosphodiesterases (PDEs) consisted of 11 subtypes (PDE1 to PDE11) and over 40
isoforms that regulate levels of cyclic guanosine monophosphate (cGMP) and cyclic …

Cyclic adenosine monophosphate (cAMP) is a key second messenger that regulates signal
transduction pathways pivotal for numerous biological functions. Intracellular cAMP levels …

Neuroprotective approaches for central nervous system regeneration have not been
successful in clinical practice so far and compounds that enhance remyelination are still not …

This article reviews the role of neuronal activity in myelin regeneration and the related
neural signaling pathways. The article points out that neuronal activity can stimulate the …

The mechanisms regulating differentiation of multipotent oligodendrocyte progenitor cells
(OPCs) into mature oligodendrocytes (OLs) are critical to our understanding of myelination …

A wide diversity of perturbations of the central nervous system (CNS) result in structural
damage to the neuroarchitecture and cellular defects, which in turn are accompanied by …

Introduction: PDEs are key enzymes in the adenosine and guanosine cyclic nucleotides
(cAMP and cGMP) signaling cascade. Their inhibition increases cyclic nucleotide levels …

Recent studies have recognized G protein-coupled receptors as important regulators of
oligodendrocyte development. GPR17, in particular, is an orphan G protein-coupled …

Abstract Phosphodiesterase 7 (PDE7) specifically hydrolyzes cyclic adenosine
monophosphate (cAMP), a second messenger that plays essential roles in cell signaling …