Molecular docking is a computational method widely used in drug discovery. Due to the
inherent inaccuracies of molecular docking, visual inspection of binding modes is a crucial …

Virtual screening has played a significant role in the discovery of small molecule inhibitors of
therapeutic targets in last two decades. Various ligand and structure-based virtual screening …

Dopamine is a biologically active amine synthesized in the central and peripheral nervous
system. This biogenic monoamine acts by activating five types of dopamine receptors (D1 …

Introduction The current drug discovery paradigm of 'one drug, multiple targets' has gained
attention from both the academic medicinal chemistry community and the pharmaceutical …

Receptor-based pharmacophore modeling is an efficient computer-aided drug design
technique that uses the structure of the target protein to identify novel leads. However, most …

Background: The pharmacophore concept in modern drug research is of great importance
and promotes the development of drug industry as indicated by the number of publications …

It has been estimated that major depressive disorder (MDD) will become the second largest
global burden among all diseases by 2030. Various types of drugs, including selective …

In the field of rare and intractable diseases, new drug development is difficult and drug
repositioning (DR) is a key method to improve this situation. In this study, we present a new …

Objective: The purpose of the review is to portray the theoretical concept on neurological
disorders from research data. Background: The freak changes in chemical response of …

Schizophrenia is a chronic, disabling mental disorder that affects about one percent of
world's population. Drugs acting on multiple targets have been demonstrated to provide …