Breast cancer is the leading cause of death from cancer in women worldwide, and the
second most common cause of death from cancer in women in the United States. Risk …

Recent advances indicate that periodontitis is driven by reciprocally reinforced interactions
between a dysbiotic microbiome and dysregulated inflammation. Inflammation is not only a …

The bone remodelling cycle replaces old and damaged bone and is a highly regulated,
lifelong process essential for preserving bone integrity and maintaining mineral …

Bone is a frequent site of metastases and typically indicates a short-term prognosis in cancer
patients. Once cancer has spread to the bones it can rarely be cured, but often it can still be …

The fully human monoclonal antibody denosumab was approved for treatment of
osteoporosis in 2010 on the basis of its potent antiresorptive activity, which produces …

Strategies for management of patients with, or at risk for, medication-related osteonecrosis of
the jaw (MRONJ) were set forth in the American Association of Oral and Maxillofacial …

Medication-related osteonecrosis of the jaw (MRONJ) is primarily an adverse side effect of
denosumab or bisphosphonates (particularly when used at high doses to prevent skeletal …

Low bone mass and strength lead to fragility fractures, for example, in elderly individuals
affected by osteoporosis or children with osteogenesis imperfecta. A decade ago, rare …

Controlling the excessive fracture burden in patients with chronic kidney disease (CKD)
Stages G4–G5D remains an impressive challenge. The reasons are 2-fold. First, the …

Background Medication-related osteonecrosis of the jaw (MRONJ), which was first reported
as bisphosphonate-related osteonecrosis of the jaw (BRONJ) in bisphosphonate users, is a …