Dietary restriction (DR) is the most robust environmental manipulation known to increase
active and healthy lifespan in many species. Despite differences in the protocols and the …

The control of body and organ growth is essential for the development of adults with proper
size and proportions, which is important for survival and reproduction. In animals, adult body …

The symbiotic microbiota profoundly affect many aspects of host physiology; however, the
molecular mechanisms underlying host-microbe cross-talk are largely unknown. Here, we …

Wing polyphenism is an evolutionarily successful feature found in a wide range of insects.
Long-winged morphs can fly, which allows them to escape adverse habitats and track …

Excess adipose fat accumulation, or obesity, is a growing problem worldwide in terms of
both the rate of incidence and the severity of obesity-associated metabolic disease. Adipose …

TORC1 (target of rapamycin complex 1) has a crucial role in the regulation of cell growth
and size. A wide range of signals, including amino acids, is known to activate TORC1. Here …

In many species, reducing nutrient intake without causing malnutrition extends lifespan [1–
3]. Like DR (dietary restriction), modulation of genes in the insulin-signaling pathway, known …

Lipid metabolism is fundamental to life. In insects, it is critical, during reproduction, flight,
starvation, and diapause. The coordination center for insect lipid metabolism is the fat body …

A great many cell types are necessary for the myriad capabilities of complex, multicellular
organisms. One interesting aspect of this diversity of cell type is that many cells in diploid …

In endoreplication cell cycles, known as endocycles, cells successively replicate their
genomes without segregating chromosomes during mitosis and thereby become polyploid …