Background During the aging process, physical capabilities (eg, muscular strength) and
cognitive functions (eg, memory) gradually decrease. Regarding cognitive functions …

The glucagon-like peptide (GLP)-1 receptor (GLP-1R) is a class BG protein–coupled
receptor (GPCR) that mediates the action of GLP-1, a peptide hormone secreted from three …

Background Lixisenatide, a glucagon-like peptide-1 receptor agonist used for the treatment
of diabetes, has shown neuroprotective properties in a mouse model of Parkinson's disease …

A connection between gut microbiota and Parkinson's disease (PD) indicates that dysbiosis
of the gut microbiota might represent a risk factor for PD. Microbiota-targeted interventions …

Importance Exenatide, a glucagon-like peptide 1 agonist used in type 2 diabetes, was
recently found to have beneficial effects on motor function in a randomized, placebo …

Abstract Sirtuins (SIRT1–SIRT7) are unique histone deacetylases (HDACs) whose activity
depends on NAD+ levels and thus on the cellular metabolic status. SIRTs regulate energy …

The insulin superfamily of peptides is essential for homeostasis as well as neuronal
plasticity, learning, and memory. Here, we show that insulin-like growth factors 1 and 2 (IGF1 …

Elderly surgical patients frequently experience postoperative delirium (POD) and the
subsequent development of postoperative cognitive dysfunction (POCD). Clinical features …

Retinal neurodegeneration is an early event in the pathogenesis of diabetic retinopathy
(DR). Since glucagon-like peptide 1 (GLP-1) exerts neuroprotective effects in the central …

Recent clinical guidelines have emphasized the importance of screening for cognitive
impairment in older adults with diabetes, however, there is still a lack of understanding about …