Functional and/or structural brain changes in response to resistance exercises and resistance training lead to cognitive improvements–a systematic review
Background During the aging process, physical capabilities (eg, muscular strength) and
cognitive functions (eg, memory) gradually decrease. Regarding cognitive functions …
cognitive functions (eg, memory) gradually decrease. Regarding cognitive functions …
Glucagon-like peptide-1 and its class BG protein–coupled receptors: a long march to therapeutic successes
C De Graaf, D Donnelly, D Wootten, J Lau… - Pharmacological …, 2016 - ASPET
The glucagon-like peptide (GLP)-1 receptor (GLP-1R) is a class BG protein–coupled
receptor (GPCR) that mediates the action of GLP-1, a peptide hormone secreted from three …
receptor (GPCR) that mediates the action of GLP-1, a peptide hormone secreted from three …
Trial of lixisenatide in early Parkinson's disease
WG Meissner, P Remy, C Giordana… - … England Journal of …, 2024 - Mass Medical Soc
Background Lixisenatide, a glucagon-like peptide-1 receptor agonist used for the treatment
of diabetes, has shown neuroprotective properties in a mouse model of Parkinson's disease …
of diabetes, has shown neuroprotective properties in a mouse model of Parkinson's disease …
Probiotic Clostridium butyricum ameliorated motor deficits in a mouse model of Parkinson's disease via gut microbiota-GLP-1 pathway
J Sun, H Li, Y Jin, J Yu, S Mao, KP Su, Z Ling… - Brain, behavior, and …, 2021 - Elsevier
A connection between gut microbiota and Parkinson's disease (PD) indicates that dysbiosis
of the gut microbiota might represent a risk factor for PD. Microbiota-targeted interventions …
of the gut microbiota might represent a risk factor for PD. Microbiota-targeted interventions …
Utility of neuronal-derived exosomes to examine molecular mechanisms that affect motor function in patients with Parkinson disease: a secondary analysis of the …
D Athauda, S Gulyani, H kumar Karnati, Y Li… - JAMA …, 2019 - jamanetwork.com
Importance Exenatide, a glucagon-like peptide 1 agonist used in type 2 diabetes, was
recently found to have beneficial effects on motor function in a randomized, placebo …
recently found to have beneficial effects on motor function in a randomized, placebo …
S irtuins and their roles in Brain Aging and Neurodegenerative disorders
H Jęśko, P Wencel, RP Strosznajder… - Neurochemical …, 2017 - Springer
Abstract Sirtuins (SIRT1–SIRT7) are unique histone deacetylases (HDACs) whose activity
depends on NAD+ levels and thus on the cellular metabolic status. SIRTs regulate energy …
depends on NAD+ levels and thus on the cellular metabolic status. SIRTs regulate energy …
Local autocrine plasticity signaling in single dendritic spines by insulin-like growth factors
The insulin superfamily of peptides is essential for homeostasis as well as neuronal
plasticity, learning, and memory. Here, we show that insulin-like growth factors 1 and 2 (IGF1 …
plasticity, learning, and memory. Here, we show that insulin-like growth factors 1 and 2 (IGF1 …
Biomarkers of postoperative delirium and cognitive dysfunction
A Fournier, R Krause, G Winterer… - Frontiers in aging …, 2015 - frontiersin.org
Elderly surgical patients frequently experience postoperative delirium (POD) and the
subsequent development of postoperative cognitive dysfunction (POCD). Clinical features …
subsequent development of postoperative cognitive dysfunction (POCD). Clinical features …
Topical administration of GLP-1 receptor agonists prevents retinal neurodegeneration in experimental diabetes
C Hernández, P Bogdanov, L Corraliza… - Diabetes, 2016 - Am Diabetes Assoc
Retinal neurodegeneration is an early event in the pathogenesis of diabetic retinopathy
(DR). Since glucagon-like peptide 1 (GLP-1) exerts neuroprotective effects in the central …
(DR). Since glucagon-like peptide 1 (GLP-1) exerts neuroprotective effects in the central …
The role of glucagon-like peptide-1 receptor agonists (GLP-1 RA) in diabetes-related neurodegenerative diseases
D Cheng, S Yang, X Zhao, G Wang - Drug design, development …, 2023 - Taylor & Francis
Recent clinical guidelines have emphasized the importance of screening for cognitive
impairment in older adults with diabetes, however, there is still a lack of understanding about …
impairment in older adults with diabetes, however, there is still a lack of understanding about …