Fever is a cardinal response to infection that has been conserved in warm-blooded and cold-
blooded vertebrates for more than 600 million years of evolution. The fever response is …

T cell migration is essential for T cell responses; it allows for the detection of cognate antigen
at the surface of antigen-presenting cells and for interactions with other cells involved in the …

Abstract Exhausted CD8 T cells (TEX) are a distinct state of T cell differentiation associated
with failure to clear chronic viruses and cancer. Immunotherapies such as PD-1 blockade …

CD8+ T cells responding to chronic infections or tumors acquire an 'exhausted'state
associated with elevated expression of inhibitory receptors, including PD-1, and impaired …

Chronic infections promote the terminal differentiation (or" exhaustion") of T cells and are
thought to preclude the formation of memory T cells. In contrast, we discovered a small …

Memory CD8 T cells that circulate in the blood and are present in lymphoid organs are an
essential component of long-lived T cell immunity. These memory CD8 T cells remain …

Central memory CD8+ T cells (Tcm) control systemic secondary infections and can protect
from chronic infection and cancer as a result of their stem-cell-like capacity to expand …

T-cells have to recognize peptides presented on MHC molecules to be activated and elicit
their effector functions. Several studies demonstrate that some peptides are more …

γδ T cells, αβ T cells, and B cells are present together in all but the most primitive
vertebrates, suggesting that each population contributes to host immune competence …

Tissues such as the skin and mucosae are frequently exposed to microbial pathogens.
Infectious agents must be quickly and efficiently controlled by our immune system, but the …