Primary ovarian insufficiency (POI) is characterized by a loss of ovarian function before the
age of 40 and account for one major cause of female infertility. POI relevance is continuously …

Forkhead box L2 (FOXL2) is a gene encoding a forkhead transcription factor preferentially
expressed in the ovary, the eyelids and the pituitary gland. Its germline mutations are …

Evolutionary fates of duplicated genes have been widely investigated in many polyploid
plants and animals, but research is scarce in recurrent polyploids. In this study, we focused …

Purpose: Chemoresistance is the main cause of treatment failure in cancer and is
associated with distant metastases and epithelial-to-mesenchymal transition (EMT). This …

Abstract Forkhead L2 (Foxl2) is expressed in ovarian granulosa cells and participates in
steroidogenesis by transcriptionally regulating target genes such as steroidogenic acute …

Adult-type granulosa cell tumor is a clinically and molecularly unique subtype of ovarian
cancer. These tumors originate from the sex cord stromal cells of the ovary and represent 3 …

Foxl2 is a member of the large family of Forkhead Box (Fox) domain transcription factors. It
emerged during the last 15 years as a key player in ovarian differentiation and oogenesis in …

The forkhead transcription factor Foxl2 plays a major role in ovarian development and
function in mice and fish, and acts as a female sex-determining gene in goat. Its functional …

Ovarian cancer remains the most lethal gynecologic malignancy, owing to late detection,
intrinsic and acquired chemoresistance and remarkable heterogeneity. Despite optimization …

The mutant protein FOXL2C134W is expressed in at least 95% of adult-type ovarian
granulosa cell tumors (AGCT) and is considered to be a driver of oncogenesis in this …