The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

Mucus is a selective barrier to particles and molecules, preventing penetration to the
epithelial surface of mucosal tissues. Significant advances in transmucosal drug delivery …

Rationale: Identification of the specific cell types expressing CFTR (cystic fibrosis [CF]
transmembrane conductance regulator) is required for precision medicine therapies for CF …

Background Reducing treatment burden is a priority for people with cystic fibrosis, whose
health has benefited from using new modulators that substantially increase CFTR protein …

Muco-Obstructive Lung Diseases This review covers the normal mechanisms of mucus
formation and how they are abnormal in common conditions—such as COPD, cystic fibrosis …

Background The airways of patients with cystic fibrosis (CF) are highly complex, subject to
various environmental conditions as well as a distinct microbiota. Pseudomonas aeruginosa …

Although better insights into the natural course of cystic fibrosis (CF) have led to treatment
approaches that have improved pulmonary health and increased the life expectancy of …

Pulmonary defense against environmental injury depends on airway mucus, which traps
inhaled toxins that are then cleared from the lungs by ciliary beating and cough. This review …

Rationale: Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR)
potentiator recently approved for patients with CF age 6 and older with the G551D mutation …

Stenotrophomonas maltophilia is an emerging multidrug-resistant global opportunistic
pathogen. The increasing incidence of nosocomial and community-acquired S. maltophilia …