Epigenetic modifications have long been recognized as an essential level in transcriptional
regulation linking behavior and environmental conditions or stimuli with biological …

BACKGROUND. Accurate detection of graft-versus-host disease (GVHD) is a major
challenge in the management of patients undergoing hematopoietic stem cell …

Background Circulating tumor DNA (ctDNA) analysis has been applied in cancer
diagnostics including lung cancer. Specifically for the early detection purpose, various …

Summary Background: Vascular endothelial cells (VECs) are an essential component of
each tissue, contribute to multiple pathologies, and are targeted by important drugs. Yet …

Neoadjuvant treatment of breast cancer is applied to an increasing extent, but treatment
response varies and side effects pose a challenge. The vitamin E isoform delta-tocotrienol …

Abstract Background Low-dose Computed Tomography (CT) is used for the detection of
pulmonary nodules, but the ambiguous risk evaluation causes overdiagnosis. Here, we …

Background Detecting organ and tissue damage is essential for early diagnosis, treatment
decisions, and monitoring disease progression. Methylation-based assays offer a promising …

The full spectrum of tissues affected by SARS-CoV-2 infection is crucial for deciphering the
heterogenous clinical course of COVID-19. Here, we analyzed DNA methylation and histone …

Background The recently identified methylation patterns specific to cell type allows the
tracing of cell death dynamics at the cellular level in health and diseases. This study used …

Next-generation methylation-aware sequencing of DNA sheds light on the fundamental role
of methylation in cellular function in health and disease. These data are commonly …