Oral tolerance is a state of systemic unresponsiveness that is the default response to food
antigens in the gastrointestinal tract, although immune tolerance can also be induced by …

Chronic liver disease when accompanied by underlying fibrosis, is characterized by an
accumulation of extracellular matrix (ECM) proteins and chronic inflammation. Although …

Allergic rhinitis (AR), chronic rhinosinusitis (CRS) and asthma often co‐exist. The one airway
model proposes that disease mechanisms occurring in the upper airway may mirror lower …

Asthma is a high-prevalence disease, still accounting for mortality and high direct and
indirect costs. It is now recognized that, despite the implementation of guidelines, a large …

Osteopontin (OPN) is a matricellular protein that mediates diverse biological functions. OPN
is involved in normal physiological processes and is implicated in the pathogenesis of a …

Recent research has led to a better but as yet incomplete understanding of the complex
roles osteopontin plays in mammalian physiology. A soluble protein found in all body fluids …

Rationale: Neonatal chronic lung disease, known as bronchopulmonary dysplasia (BPD),
remains a serious complication of prematurity despite advances in the treatment of …

Dendritic cells (DCs) are generally held responsible for initiating and maintaining allergic T
helper 2 (TH2)-cell responses to inhaled allergens in asthma. Although the epithelium was …

Lung dendritic cells (DCs) bridge innate and adaptive immunity, and depending on context,
they also induce a Th1, Th2, or Th17 response to optimally clear infectious threats …

Dendritic cells (DCs) initiate and maintain adaptive T helper 2 (Th2) cell responses to
inhaled allergens in asthma. Various functions like antigen uptake, migration to the draining …