Post-translational modifications (PTM) decorate proteins to provide functional heterogeneity
to an existing proteome. The large number of known PTMs highlights the many ways that …

Sirtuins or Sir2 family of proteins are a class of NAD+ dependent protein deacetylases which
are evolutionarily conserved from bacteria to humans. Some sirtuins also exhibit mono-ADP …

The emerging view of Nε-lysine acetylation in eukaryotes is of a relatively abundant post-
translational modification (PTM) that has a major impact on the function, structure, stability …

Acylation of biomolecules (eg, proteins and small molecules) is a process that occurs in cells
of all domains of life and has emerged as a critical mechanism for the control of many …

Protein lysine acetylation plays a key role in regulating chromatin dynamics, gene
expression and metabolic pathways in eukaryotes, and, thus, contributes to diverse cellular …

Acetylation is a posttranslational modification conserved in all domains of life that is carried
out by N-acetyltransferases. While acetylation can occur on N α-amino groups, this review …

ABSTRACT N ε-Lysine acetylation is now recognized as an abundant posttranslational
modification (PTM) that influences many essential biological pathways. Advancements in …

Although protein acetylation is widely observed, it has been associated with few specific
regulatory functions making it poorly understood. To interrogate its functionality, we …

The lysine acetylation of proteins is a reversible post-translational modification that plays a
critical regulatory role in both eukaryotes and prokaryotes. Mycobacterium tuberculosis is a …

Protein acetylation has historically been considered a predominantly eukaryotic
phenomenon. Recent evidence, however, supports the hypothesis that acetylation broadly …