OBJECTIVES Literature is scarce on the management of patients using direct oral
anticoagulants (DOACs) undergoing elective, urgent and emergency surgery. Therefore, we …

Background Bleeding after surgery on the thoracic aorta is a frequent complication, and can
be associated with a significant increase in morbidity and mortality. Recombinant activated …

Background Coagulopathy following cardiac surgery is associated with considerable blood
product transfusion and high morbidity and mortality. The treatment of coagulopathy …

Pediatric cardiac surgery patients are predisposed to blood loss. Blood product
administration can lead to complications. Prothrombin complex concentrates (PCCs) offer …

Key questions in bleeding management are “Why does my patient bleed?” and “How to fix
it?” To answer the first question, the high negative predictive value of viscoelastic testing can …

The current data supports the use of 4F-PCC instead of FFP as the primary hemostatic agent
in cases of major bleeding in cardiac surgery. The use of PCCs is associated with reduced …

As perioperative bleeding continues to be a major source of morbidity and mortality in
cardiac surgery, the search continues for an ideal hemostatic agent for use in this patient …

Статья представляет методические рекомендации по диагностике и интенсивной
терапии ДВС-синдрома при массивной кровопотере в акушерстве. Рассмотрены …

Background: Recombinant factor VIIa (rFVIIa) and prothrombin concentrate complex (PCC)
are used for uncontrolled bleeding in cardiac surgery (CS), however, there are limited direct …

Factor XI deficiency is associated with a bleeding tendency in some patients. Factor XI helps
to reduce fibrinolysis. Bleeding risk is increased in factor XI-deficient patients during …