Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis
PH Nguyen, A Ramamoorthy, BR Sahoo… - Chemical …, 2021 - ACS Publications
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
Liquid-liquid phase separation of α-synuclein: a new mechanistic insight for α-synuclein aggregation associated with Parkinson's disease pathogenesis
Aberrant aggregation of the misfolded presynaptic protein, α-Synuclein (α-Syn) into Lewy
body (LB) and Lewy neuritis (LN) is a major pathological hallmark of Parkinson's disease …
body (LB) and Lewy neuritis (LN) is a major pathological hallmark of Parkinson's disease …
The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells
The self-assembly of α-synuclein (αS) into intraneuronal inclusion bodies is a key
characteristic of Parkinson's disease. To define the nature of the species giving rise to …
characteristic of Parkinson's disease. To define the nature of the species giving rise to …
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
Oligomeric species populated during the aggregation process of α-synuclein have been
linked to neuronal impairment in Parkinson's disease and related neurodegenerative …
linked to neuronal impairment in Parkinson's disease and related neurodegenerative …
The role of lipids interacting with α-synuclein in the pathogenesis of Parkinson's disease
C Galvagnion - Journal of Parkinson's disease, 2017 - content.iospress.com
Abstract α-synuclein is a small protein abundantly expressed in the brain and mainly located
in synaptic terminals. The conversion of α-synuclein into oligomers and fibrils is the hallmark …
in synaptic terminals. The conversion of α-synuclein into oligomers and fibrils is the hallmark …
Effects of in vivo conditions on amyloid aggregation
One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …
govern protein misfolding and aggregation, which is a highly complex process that is …
The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition
Abstract α-Synuclein (αS) is a presynaptic disordered protein whose aberrant aggregation is
associated with Parkinson's disease. The functional role of αS is still debated, although it …
associated with Parkinson's disease. The functional role of αS is still debated, although it …
Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function
Phosphorylation of α-synuclein at the serine-129 site (α-syn Ser129P) is an established
pathologic hallmark of synucleinopathies and a therapeutic target. In physiologic states, only …
pathologic hallmark of synucleinopathies and a therapeutic target. In physiologic states, only …
Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons
S Santhosh Kumar, NN Naseri, SR Pather… - Science …, 2024 - science.org
Alpha-synuclein (αSyn) protein levels correlate with the risk and severity of Parkinson's
disease and related neurodegenerative diseases. Lowering αSyn is being actively …
disease and related neurodegenerative diseases. Lowering αSyn is being actively …
ɑ-Synuclein strains and seeding in Parkinson's disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and …
W Peelaerts, L Bousset, V Baekelandt, R Melki - Cell and tissue research, 2018 - Springer
Several age-related neurodegenerative disorders are characterized by the deposition of
aberrantly folded endogenous proteins. These proteins have prion-like propagation and …
aberrantly folded endogenous proteins. These proteins have prion-like propagation and …