Many of the motor symptoms of Parkinson disease (PD) can be preceded, sometimes for
several years, by non-motor symptoms that include hyposmia, sleep disorders, depression …

The use of animals as models of human physiology is, and has been for many years, an
indispensable tool for understanding the mechanisms of human disease. In Parkinson's …

Parkinson's disease (PD) is a complex, multisystem disorder characterised by α-synuclein
(SNCA) pathology, degeneration of nigrostriatal dopaminergic neurons, multifactorial …

Dysautonomia is a common non-motor symptom in Parkinson's disease (PD). Most
dysautonomic symptoms appear due to alterations in the peripheral nerves of the autonomic …

Patients with Parkinson's disease (PD) manifest nonmotor and motor symptoms. Autonomic
cardiovascular dysregulation is a common nonmotor manifestation associated with …

Objective Evaluate the effects caused by L-DOPA on cardiovascular and autonomic
parameters in an animal model of Parkinsonism induced by 6-hydroxydopamine (6-OHDA) …

The incidence of Parkinson's disease (PD) is increasing worldwide. Although the PD
hallmark is the motor impairments, nonmotor dysfunctions are now becoming more …

Nonmotor symptoms of Parkinson's disease (PD) range from neuropsychiatric, cognitive to
sleep and sensory disorders and can arise from the disease process as well as from drug …

We investigated the genome of a 5-year-old male who presented with global developmental
delay (motor, cognitive, and speech), hypotonia, possibly ataxia, and cerebellar hypoplasia …

Aims Although reduced life expectancy in Parkinson's Disease (PD) patients has been
related to severe cardiac arrhythmias due to autonomic dysfunctions, its molecular …