This review discusses the experimental and clinical data which indicate that chronic cerebral
hypoperfusion can affect metabolic, anatomic, and cognitive function adversely. In aged but …

Although a relationship is commonly accepted between coronary and carotid arterial
disease, suggesting that atherosclerosis is a systemic condition, the extent of this …

Background and Purpose—Blood supply through collateral pathways improves regional
cerebral blood flow and may protect against ischemic events. The effect of collaterals on the …

Background and Purpose—Evidence suggests that an alteration in cerebral hemodynamics
plays a relevant role in the occurrence of stroke in patients with carotid occlusion. The …

Aminophosphonic acids are an important group of medicinal compounds, and their
synthesis has been a focus of considerable attention in synthetic organic chemistry as well …

Background: Autopsy studies show a higher prevalence of circle of Willis anomalies in
brains with signs of ischemic infarction. Our goal was to examine the collateral function of …

Background and Purpose—Four-dimensional phase-contrast magnetic resonance imaging
enables quantification of blood flow rate (BFR; mL/min) in multiple cerebral arteries …

Carotid artery disease is common and increases the risk of stroke. However, there is wide
variability on the severity of clinical manifestations of carotid disease, ranging from …

Detailed knowledge of the cerebral hemodynamics is important for a variety of clinical
applications. Cerebral perfusion depends not only on the status of the diseased vessels but …

Carotid artery stenosis (CAS) is a consequence of systemic atherosclerotic disease affecting
the aging populations of the Western world. CAS is frequently associated with cognitive …