Itch is a unique sensory experience that is encoded by genetically distinguishable neurons
both in the peripheral nervous system (PNS) and central nervous system (CNS) to elicit a …

The multimodal properties of the human somatosensory system continue to be unravelled.
There is mounting evidence that one of these submodalities—touch—has another …

The MRGPRX family of receptors (MRGPRX1–4) is a family of mas-related G-protein-
coupled receptors that have evolved relatively recently. Of these, MRGPRX2 and MRGPRX4 …

More than twelve morphologically and physiologically distinct subtypes of primary
somatosensory neuron report salient features of our internal and external environments,,–. It …

Chronic pain affects one in five of the general population and is the third most important
cause of disability-adjusted life-years globally. Unfortunately, treatment remains inadequate …

Mast cells (MCs), which are granulated tissue-resident cells of hematopoietic lineage,
contribute to vascular homeostasis, innate/adaptive immunity, and wound healing. However …

Background Although the cytokine IL-31 has been implicated in inflammatory and lymphoma-
associated itch, the cellular basis for its pruritic action is yet unclear. Objective We sought to …

For centuries, itch was categorized as a submodality of pain. Recent research over the last
decade has led to the realization that itch is in fact a separate and distinct, albeit closely …

Neurotransmission between neurons, which can occur over the span of a few milliseconds,
relies on the controlled release of small molecule neurotransmitters, many of which are …

Itch-specific neurons have been sought for decades. The existence of such neurons has
been doubted recently as a result of the observation that itch-mediating neurons also …