[HTML][HTML] Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics

LE McCoubrey, A Favaron, A Awad, M Orlu… - Journal of Controlled …, 2023 - Elsevier
Colonic drug delivery can facilitate access to unique therapeutic targets and has the
potential to enhance drug bioavailability whilst reducing off-target effects. Delivering drugs to …

Connected healthcare: Improving patient care using digital health technologies

A Awad, SJ Trenfield, TD Pollard, JJ Ong… - Advanced Drug Delivery …, 2021 - Elsevier
Now more than ever, traditional healthcare models are being overhauled with digital
technologies of Healthcare 4.0 increasingly adopted. Worldwide, digital devices are …

[HTML][HTML] Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review

Z Vinarov, M Abdallah, JAG Agundez… - European Journal of …, 2021 - Elsevier
The absorption of oral drugs is frequently plagued by significant variability with potentially
serious therapeutic consequences. The source of variability can be traced back to …

Machine learning and deep learning applications in microbiome research

R Hernández Medina, S Kutuzova… - ISME …, 2022 - academic.oup.com
The many microbial communities around us form interactive and dynamic ecosystems called
microbiomes. Though concealed from the naked eye, microbiomes govern and influence …

Harnessing artificial intelligence for the next generation of 3D printed medicines

M Elbadawi, LE McCoubrey, FKH Gavins… - Advanced Drug Delivery …, 2021 - Elsevier
Artificial intelligence (AI) is redefining how we exist in the world. In almost every sector of
society, AI is performing tasks with super-human speed and intellect; from the prediction of …

Disrupting 3D printing of medicines with machine learning

M Elbadawi, LE McCoubrey, FKH Gavins… - Trends in …, 2021 - cell.com
3D printing (3DP) is a progressive technology capable of transforming pharmaceutical
development. However, despite its promising advantages, its transition into clinical settings …

Gut microbiome immaturity and childhood acute lymphoblastic leukaemia

I Peppas, AM Ford, CL Furness, MF Greaves - Nature Reviews Cancer, 2023 - nature.com
Acute lymphoblastic leukaemia (ALL) is the most common cancer of childhood. Here, we
map emerging evidence suggesting that children with ALL at the time of diagnosis may have …

A review of state-of-the-art on enabling additive manufacturing processes for precision medicine

A Awad, A Goyanes, AW Basit… - Journal of …, 2023 - asmedigitalcollection.asme.org
Precision medicine is an emerging healthcare delivery approach that considers variability
between patients, such as genetic makeups, in contrast to the current one-size-fits-all …

Predicting drug-microbiome interactions with machine learning

LE McCoubrey, S Gaisford, M Orlu, AW Basit - Biotechnology advances, 2022 - Elsevier
Pivotal work in recent years has cast light on the importance of the human microbiome in
maintenance of health and physiological response to drugs. It is now clear that …

The intestinal and biliary microbiome in autoimmune liver disease—current evidence and concepts

T Liwinski, M Heinemann, C Schramm - Seminars in Immunopathology, 2022 - Springer
Autoimmune liver diseases are a group of immune-mediated liver diseases with three
distinct entities, including autoimmune hepatitis, primary biliary cholangitis, and primary …