China's population has rapidly aged over the recent decades of social and economic
development as neurodegenerative disorders have proliferated, especially Alzheimer's …

Purpose In the last decade, the research community has focused on defining reliable
biomarkers for the early detection of Alzheimer's disease (AD) pathology. In 2017, the …

随着我国社会经济的发展和人口老龄化进程的加速, 与成功老龄化对应的老年性疾病对国民的
影响日益突出, 其中阿尔茨海默病(Aizheimer's disease, AD) 及相关认知障碍尤为突出和显著 …

Background Disease-modifying drug use necessitates better Alzheimer disease (AD)
detection. Mild cognitive impairment (MCI) leverages cognitive decline to identify the risk …

Background Up to now, there are no clinically available minimally invasive biomarkers to
accurately identify mild cognitive impairment (MCI) patients who are at greater risk to …

Background and purpose Executive function impairment, a slight but noticeable cognitive
deficit in mild cognitive impairment (MCI) patients, is influenced by gamma-aminobutyric …

Abnormal accumulation of Tau protein is closely associated with neurodegeneration and
cognitive impairment and it is a biomarker of neurodegeneration in the dementia field …

Methylation levels of the mitochondrial displacement loop (D-loop) region have been
reported to be altered in the brain and blood of Alzheimer's disease (AD) patients. Moreover …

Mild cognitive impairment (MCI) is often considered an early stage of dementia, with
estimated rates of progression to dementia up to 80–90% after approximately 6 years from …

INTRODUCTION Amnestic mild cognitive impairment (aMCI) is emerging as a
heterogeneous condition. METHODS We looked at a cohort of N= 207 aMCI subjects, with …