Protein arginine methyltransferases: promising targets for cancer therapy
JW Hwang, Y Cho, GU Bae, SN Kim… - Experimental & molecular …, 2021 - nature.com
Protein methylation, a post-translational modification (PTM), is observed in a wide variety of
cell types from prokaryotes to eukaryotes. With recent and rapid advancements in epigenetic …
cell types from prokaryotes to eukaryotes. With recent and rapid advancements in epigenetic …
[HTML][HTML] Protein arginine methyltransferase 5 (PRMT5) dysregulation in cancer
Protein arginine methyltransferases (PRMTs) are known for their ability to catalyze
methylation of specific arginine residues in a wide variety of cellular proteins, which are …
methylation of specific arginine residues in a wide variety of cellular proteins, which are …
Targeting p38 MAP kinase signaling in cancer through post-translational modifications
X Zou, M Blank - Cancer letters, 2017 - Elsevier
The p38 MAPK signaling pathway is a key signal transduction cascade that cancer cells
employ to sense and adapt to a plethora of environmental stimuli, and has attracted much …
employ to sense and adapt to a plethora of environmental stimuli, and has attracted much …
[HTML][HTML] PRMT5 in gene regulation and hematologic malignancies
Arginine methylation is a common posttranslational modification that governs important
cellular processes and impacts development, cell growth, proliferation, and differentiation …
cellular processes and impacts development, cell growth, proliferation, and differentiation …
The regulatory and signaling mechanisms of the ASK family
T Nishida, K Hattori, K Watanabe - Advances in biological regulation, 2017 - Elsevier
Apoptosis signal-regulating kinase 1 (ASK1) was identified as a MAP3K that activates the
JNK and p38 pathways, and subsequent studies have reported ASK2 and ASK3 as …
JNK and p38 pathways, and subsequent studies have reported ASK2 and ASK3 as …
ASK1-K716R reduces neuroinflammation and white matter injury via preserving blood–brain barrier integrity after traumatic brain injury
S Meng, H Cao, Y Huang, Z Shi, J Li, Y Wang… - Journal of …, 2023 - Springer
Background Traumatic brain injury (TBI) is a significant worldwide public health concern that
necessitates attention. Apoptosis signal-regulating kinase 1 (ASK1), a key player in various …
necessitates attention. Apoptosis signal-regulating kinase 1 (ASK1), a key player in various …
Phosphorylation of LSD1 at Ser112 is crucial for its function in induction of EMT and metastasis in breast cancer
Purpose LSD1 is overexpressed in various cancers including breast cancer, but its
functional roles in tumourigenesis are not fully understood. This study aims at revealing the …
functional roles in tumourigenesis are not fully understood. This study aims at revealing the …
GlPRMT5 inhibits GlPP2C1 via symmetric dimethylation and regulates the biosynthesis of secondary metabolites in Ganoderma lucidum
Z Wang, H Qiu, Y Li, M Zhao, R Liu - Communications Biology, 2024 - nature.com
PRMT5, a type II arginine methyltransferase, is involved in transcriptional regulation, RNA
processing and other biological processes and signal transduction. Secondary metabolites …
processing and other biological processes and signal transduction. Secondary metabolites …
Pleiotropic properties of ASK1
C Sakauchi, H Wakatsuki, H Ichijo, K Hattori - Biochimica et Biophysica …, 2017 - Elsevier
Background Apoptosis signal-regulating kinase 1 (ASK1), also known as mitogen-activated
protein kinase kinase kinase 5 (MAP3K5), has the potential to induce cellular apoptosis …
protein kinase kinase kinase 5 (MAP3K5), has the potential to induce cellular apoptosis …