A diverse array of sex determination (SD) mechanisms, encompassing environmental to
genetic, have been found to exist among vertebrates, covering a spectrum from fixed SD …

Sertoli cells are the orchestrators of spermatogenesis; they support fetal germ cell
commitment to the male pathway and are essential for germ cell development, from …

The complex morphology of the Sertoli cells and their interactions with germ cells has been
a focus of investigators since they were first described by Enrico Sertoli. In the past 50 years …

The purpose of this review is to describe the endocrine and local testicular factors that
contribute to the regulation of the blood-testis barrier (BTB), using information gained from in …

Epigenetic reprogramming plays a pivotal role during embryogenesis, including both
covalent and non-covalent modifications to chromatin. In this study, we investigated the role …

Blood-testis barrier (BTB) creates a particular compartment in the seminiferous epithelium.
Contacting Sertoli cell-Sertoli cell plasma membranes possess specialized junction proteins …

The use of nanoscale materials for different biomedical applications has grown a lot in the
last years and raised several concerns about toxic effects on human health. Several studies …

The intricate molecular and cellular interactions between spermatogonial stem cells (SSCs)
and their cognate niche form the basis for life-long sperm production. To maintain long-term …

Mammalian spermatogenesis is sustained by mitotic germ cells with self-renewal potential
known as undifferentiated spermatogonia. Maintenance of undifferentiated spermatogonia …

Gonadotropin therapy to treat specific male infertility disorders associated with
hypogonadotropic hypogonadism is evidence-based and effective in restoring …