Patients with ovarian cancer usually present with advanced disease, and the disease is
generally managed with surgical resection followed by platinum-based chemotherapy …

Protein kinase B or Akt (PKB/Akt) is a serine/threonine kinase, which in mammals comprises
three highly homologous members known as PKBα (Akt1), PKBβ (Akt2), and PKBγ (Akt3) …

BRCA1 immunostaining reveals discrete, nuclear foci during S phase of the cell cycle.
Human Rad51, a homolog of bacterial RecA, behaves similarly. The two proteins were …

We have identified a novel protein, BAP1, which binds to the RING finger domain of the
Breast/Ovarian Cancer Susceptibility Gene product, BRCA1. BAP1 is a nuclear-localized …

BRCA1 interacts in vivo with a novel protein, BACH1, a member of the DEAH helicase
family. BACH1 binds directly to the BRCT repeats of BRCA1. A BACH1 derivative, bearing a …

BRCA1 localizes to discrete nuclear foci (dots) during S phase. Hydroxyurea-mediated DNA
synthesis arrest of S phase MCF7 cells led to a loss of BRCA1 from these structures …

Abstract The Breast Cancer Susceptibility Genes, BRCA1 and BRCA2, are the dynamic
regulators of genomic integrity. Inherited mutations in these genes are associated with the …

Lack of molecular targets in estrogen receptor-negative (ER-negative) breast cancer is a
major therapeutic hurdle. We studied NF-κB activation in human breast tumors and in …

BRCA1 and BRCA2 account for most cases of familial, early onset breast and/or ovarian
cancer and encode products that each interact with hRAD51. Results presented here show …

BRCA1 is a well-established tumor suppressor gene, which is frequently mutated in familial
breast and ovarian cancers. The gene product of BRCA1 functions in a number of cellular …