Background Manual therapy (MT) and exercise have been extensively used to treat people
with musculoskeletal conditions such as temporomandibular disorders (TMD). The evidence …

Background Chronic non‐cancer pain, a disabling and distressing condition, is common in
adults. It is a global public health problem and economic burden on health and social care …

High quality protocols facilitate proper conduct, reporting, and external review of clinical
trials. However, the completeness of trial protocols is often inadequate. To help improve the …

We report a meta-analysis of virtual reality (VR) interventions for anxiety and depression
outcomes, as well as treatment attrition. We included randomized controlled trials comparing …

Background: Previous meta-analyses comparing the efficacy of psychotherapeutic
interventions for depression were clouded by a limited number of within-study treatment …

BackgroundPost-traumatic stress disorder (PTSD) is a potentially chronic and disabling
disorder affecting a significant minority of people exposed to trauma. Various psychological …

Published evidence suggests that aspects of trial design lead to biased intervention effect
estimates, but findings from different studies are inconsistent. This study combined data from …

Background Groin injuries represent a considerable problem in male football. Previous groin-
specific prevention programmes have not shown a significant reduction in groin injury rates …

Background: Viscosupplementation, the intra-articular injection of hyaluronic acid, is widely
used for symptomatic knee osteoarthritis. Purpose: To assess the benefits and risks of …

Background Cerebral palsy (CP) is a neurodevelopmental disorder resulting from an injury
to the developing brain. It is the most common form of childhood disability with prevalence …