[HTML][HTML] The genetics of addiction—a translational perspective

A Agrawal, KJH Verweij, NA Gillespie, AC Heath… - Translational …, 2012 - nature.com
Addictions are serious and common psychiatric disorders, and are among the leading
contributors to preventable death. This selective review outlines and highlights the need for …

New insights into the genetics of addiction

MD Li, M Burmeister - Nature Reviews Genetics, 2009 - nature.com
Drug addiction is a common brain disorder that is extremely costly to the individual and to
society. Genetics contributes significantly to vulnerability to this disorder, but identification of …

[HTML][HTML] Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis …

S Stringer, CC Minică, KJH Verweij, H Mbarek… - Translational …, 2016 - nature.com
Cannabis is the most widely produced and consumed illicit psychoactive substance
worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence …

Common heritable contributions to low-risk trauma, high-risk trauma, posttraumatic stress disorder, and major depression

CE Sartor, JD Grant, MT Lynskey… - Archives of general …, 2012 - jamanetwork.com
Context Understanding the relative contributions of genetic and environmental factors to
trauma exposure, posttraumatic stress disorder (PTSD), and major depressive disorder …

[HTML][HTML] Pharmacogenetics of cannabinoids

S Hryhorowicz, M Walczak… - European journal of …, 2018 - Springer
Although the application of medical marijuana and cannabinoid drugs is controversial, it is a
part of modern-day medicine. The list of diseases in which cannabinoids are promoted as a …

[HTML][HTML] Cannabis pharmacogenomics: a path to personalized medicine

M Babayeva, ZG Loewy - Current Issues in Molecular Biology, 2023 - mdpi.com
Cannabis and related compounds have created significant research interest as a promising
therapy in many disorders. However, the individual therapeutic effects of cannabinoids and …

[HTML][HTML] Whole exome sequencing in females with autism implicates novel and candidate genes

MG Butler, SK Rafi, W Hossain, DA Stephan… - International journal of …, 2015 - mdpi.com
Classical autism or autistic disorder belongs to a group of genetically heterogeneous
conditions known as Autism Spectrum Disorders (ASD). Heritability is estimated as high as …

Candidate genes for cannabis use disorders: findings, challenges and directions

A Agrawal, MT Lynskey - Addiction, 2009 - Wiley Online Library
Aim Twin studies have shown that cannabis use disorders (abuse/dependence) are highly
heritable. This review aims to:(i) review existing linkage studies of cannabis use disorders …

[HTML][HTML] The biology of addiction

B MacNicol - Canadian Journal of Anesthesia/Journal canadien d' …, 2017 - Springer
In this narrative review, the neurobiological mechanisms underlying substance abuse and
addiction are discussed with a particular emphasis on the mechanisms that promote …

Cannabis dependence in the San Francisco Family Study: age of onset of use, DSM-IV symptoms, withdrawal, and heritability

CL Ehlers, IR Gizer, C Vieten, DA Gilder, GM Stouffer… - Addictive …, 2010 - Elsevier
Cannabis is the most widely used illicit drug in the United States, yet the role of genetics in
individual symptoms associated with cannabis use disorders has not been evaluated. The …