The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …

Perturbations in metabolic processes are associated with diseases such as obesity, type 2
diabetes mellitus, certain infections and some cancers. A resurgence of interest in creatine …

The precursor cells for metabolically beneficial beige adipocytes can alternatively become
fibrogenic and contribute to adipose fibrosis. We found that cold exposure or β3-adrenergic …

Adipose tissue comprises adipocytes and many other cell types that engage in dynamic
crosstalk in a highly innervated and vascularized tissue matrix. Although adipose tissue has …

Pharmacologic inhibition of the renal sodium/glucose cotransporter-2 induces glycosuria
and reduces glycemia. Given that SGLT2 inhibitors (SGLT2i) reduce mortality and …

Obesity results from energy imbalance, when energy intake exceeds energy expenditure.
Brown adipose tissue (BAT) drives non-shivering thermogenesis which represents a …

The consumption of a high-fat, low-carbohydrate diet (ketogenic diet) has diverse effects on
health and is expected to have therapeutic value in neurological disorders, metabolic …

Growing evidence supports the efficacy of ketogenic diets for inducing weight loss, but there
are also potential health risks due to their unbalanced nutrient composition. We aim at …

The ketogenic diet (KD) is characterized by minimal carbohydrate, moderate protein, and
high fat intake, leading to ketosis. It is recognized for its efficiency in weight loss, metabolic …

Glucocorticoid signaling is fundamental in healthy stress coping and in the pathophysiology
of stress-related diseases, such as post-traumatic stress disorder (PTSD). Glucocorticoids …