This work is one of our efforts to discover potent anticancer agents. We modified the most
promising derivative of our previous work concerned with the development of VEGFR-2 …

Based on quinazoline, quinoxaline, and nitrobenzene scaffolds and on pharmacophoric
features of VEGFR-2 inhibitors, 17 novel compounds were designed and synthesised …

In our effort to discover potential immunomodulatory anticancer candidates, a new series of
quinazolinone derivatives carrying glutarimide moiety were designed and synthesized as …

Sixteen new thalidomide analogs were synthesized. The new candidates showed potent in
vitro antiproliferative activities against three human cancer cell lines, namely hepatocellular …

Immunomodulatory medications like thalidomide and its analogs prevent the production of
some proinflammatory cytokines linked to cancer. A new series of thalidomide analogs were …

Background Cancer is still a major world health threat, causing a high rate of mortality.
VEGFR-2 inhibitor anticancer agents are of great significance. However, they showed some …

It is evident that cancer is a serious disease with a growing incidence and high mortality rate.
Based on the CRBN binding properties of glutarimide moiety of thalidomide molecule, and …

Colorectal cancer (CRC) is a malignant tumor recognized as a major cause of morbidity and
mortality throughout the world. Therefore, novel liposomes of oleic acid coated with camel α …

Membrane E-cadherin is one of the proteins whose expression affects cancer cell migration
and adhesion. The design of peptide drugs that target such cancer cell-specific …

As an extension to our previous work for the development of new thalidomide analogs, the
current work offers new insights into the immunomodulatory and anticancer activities of …