Lysophospholipid mediators in health and disease
Lysophospholipids, exemplified by lysophosphatidic acid (LPA) and sphingosine 1-
phosphate (S1P), are produced by the metabolism and perturbation of biological …
phosphate (S1P), are produced by the metabolism and perturbation of biological …
[HTML][HTML] Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer
Aerobic exercise is associated with decreased cancer incidence and cancer-associated
mortality. However, little is known about the effects of exercise on pancreatic ductal …
mortality. However, little is known about the effects of exercise on pancreatic ductal …
Germinal centers: programmed for affinity maturation and antibody diversification
O Bannard, JG Cyster - Current opinion in immunology, 2017 - Elsevier
Highlights•GCs can support B cells with a range of affinities for the inducing antigen.•GC
selection involves a LZ bottleneck and differential expansion in the DZ.•Transition between …
selection involves a LZ bottleneck and differential expansion in the DZ.•Transition between …
Sphingosine 1-phosphate receptor-targeted therapeutics in rheumatic diseases
Abstract Sphingosine 1-phosphate (S1P), which acts via G protein-coupled S1P receptors
(S1PRs), is a bioactive lipid essential for vascular integrity and lymphocyte trafficking. The …
(S1PRs), is a bioactive lipid essential for vascular integrity and lymphocyte trafficking. The …
Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances
Sphingosine kinases (isoforms SK1 and SK2) catalyse the formation of a bioactive lipid,
sphingosine 1-phosphate (S1P). S1P is a well-established ligand of a family of five S1P …
sphingosine 1-phosphate (S1P). S1P is a well-established ligand of a family of five S1P …
Exit strategies: S1P signaling and T cell migration
Whereas the role of sphingosine 1-phosphate receptor 1 (S1PR1) in T cell egress and the
regulation of S1P gradients between lymphoid organs and circulatory fluids in homeostasis …
regulation of S1P gradients between lymphoid organs and circulatory fluids in homeostasis …
Finding a way out: S1P signaling and immune cell migration
AAL Baeyens, SR Schwab - Annual review of immunology, 2020 - annualreviews.org
The signaling lipid sphingosine 1-phosphate (S1P) plays critical roles in an immune
response. Drugs targeting S1P signaling have been remarkably successful in treatment of …
response. Drugs targeting S1P signaling have been remarkably successful in treatment of …
Monocyte-derived S1P in the lymph node regulates immune responses
A Baeyens, S Bracero, VS Chaluvadi… - Nature, 2021 - nature.com
The lipid chemoattractant sphingosine 1-phosphate (S1P) guides cells out of tissues, where
the concentration of S1P is relatively low, into circulatory fluids, where the concentration of …
the concentration of S1P is relatively low, into circulatory fluids, where the concentration of …
[HTML][HTML] Mechanotransduction activates RhoA in the neighbors of apoptotic epithelial cells to engage apical extrusion
K Duszyc, GA Gomez, AK Lagendijk, MK Yau… - Current Biology, 2021 - cell.com
Epithelia must eliminate apoptotic cells to preserve tissue barriers and prevent inflammation.
1 Several different mechanisms exist for apoptotic clearance, including efferocytosis 2, 3 and …
1 Several different mechanisms exist for apoptotic clearance, including efferocytosis 2, 3 and …