Proteomic instability is causally related to human diseases. In guarding proteome stability,
the heat shock factor 1 (HSF1)-mediated proteotoxic stress response plays a pivotal role …

Aneuploidy is a hallmark of cancer and a major cause of miscarriages in humans. It is
caused by chromosome segregation errors during cell divisions. Evidence is mounting that …

Aneuploidy is a hallmark of human cancers, but the effects of aneuploidy on protein
expression remain poorly understood. To uncover how chromosome copy number changes …

Up to 80% of human cancers, in particular solid tumors, contain cells with abnormal
chromosomal numbers, or aneuploidy, which is often linked with marked chromosomal …

An increased tendency of genomic alterations during the life cycle of cells leads to genomic
instability, which is a major driving force for tumorigenesis. A considerable fraction of tumor …

Over the last decade, the CMGC kinase DYRK2 has been reported as a tumor suppressor
across various cancers triggering major antitumor and proapoptotic signals in breast, colon …

Aneuploidy is highly detrimental during development yet common in cancers and
pathogenic fungi–what gives rise to differences in aneuploidy tolerance remains unclear …

Individuals carrying an aberrant number of chromosomes can vary widely in their expression
of aneuploidy phenotypes. A major unanswered question is the degree to which an …

Aneuploidy produces myriad consequences in health and disease, yet models of the
deleterious effects of chromosome amplification are still widely debated. To distinguish the …

Aneuploidy (ie, abnormal chromosome number) is the leading cause of miscarriage and
congenital defects in humans. Moreover, aneuploidy is ubiquitous in cancer. The deleterious …