Type 2 diabetes (T2D) is caused by insufficient insulin secretion from pancreatic β cells. To
identify candidate genes contributing to T2D pathophysiology, we studied human pancreatic …

Dysregulation of gene expression in islets from patients with type 2 diabetes (T2D) might be
causally involved in the development of hyperglycemia, or it could develop as a …

To explore the effects immune‐isolating encapsulation has on the insulin secretion of
pancreatic islets and to improve our ability to quantitatively describe the glucose‐stimulated …

Type 1 diabetes mellitus is an autoimmune disease that is characterized by the destruction
of the islets of Langerhans cells which produce insulin. The current gold standard treatment …

Subcutaneous tissue is a promising site for islet transplantation, but poor engraftment, due to
hypoxia and low vascularity, hinders its prevalence. However, oxygen partial pressure (pO2) …

The success of islet transplantation in both basic research and clinical settings has proven
that cell therapy has the potential to cure diabetes. Islets intended for transplantation are …

Aim The variation in quality between the human islet samples represents a major problem
for research, especially when used as control material. The assays assessing the quality of …

Characterization of gene expression in pancreatic islets and its alteration in type 2 diabetes
(T2D) are vital in understanding islet function and T2D pathogenesis. We leveraged RNA …

Intra‐portal islet transplantation is currently the only clinically approved beta cell
replacement therapy, but its outcome is hindered by limited cell survival due to a …

Quantity and quality assessment of human pancreatic islets are essential processes to
define a safe and potent quality product used for clinical transplantation. The conventional …