Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases
responsible for tissue remodeling and degradation of extracellular matrix (ECM) proteins …

Overlapping risks for cancer and cardiovascular diseases (CVD), the two leading causes of
mortality worldwide, suggest a shared biology between these diseases. The role of …

Vascular calcification, a common pathological basis of vascular disease, is caused by
various diseases and is an independent risk factor for cardiovascular events. Therefore …

Extracellular vesicles (EVs) are small vesicles released by the majority of cells in response
to cell activation or death stimuli. They are grouped as small EVs or exosomes, large EVs …

In recent decades, extracellular vesicles have been recognized as “very important
particles”(VIPs) associated with aging and age-related disease. During the 1980s …

Senescence is a state of proliferative arrest which has been described as a protective
mechanism against the malignant transformation of cells. However, senescent cells have …

Osteoporosis (OP) and cardiovascular diseases (CVD) are both important causes of
mortality and morbidity in aging patients. There are common mechanisms underlying the …

Aging is one of the hottest topics in biomedical research. Advances in research and
medicine have helped to preserve human health, leading to an extension of life expectancy …

Aging of the vasculature, which is integral to the functioning of literally all human organs,
serves as a fundamental physiological basis for age-related alterations as well as a shared …

The disease criteria used by the World Health Organization (WHO) were applied to human
biological aging in order to assess whether aging can be classified as a disease. These …